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Getting to the heart of an unusual kinetochore
The Mis12 complex forms the central scaffold of the kinetochore and serves to bridge the chromatin and microtubule-binding activities of the inner and outer layers, respectively. Two recent studies provide new structural insights into the formation of this complex, and highlight some intriguing adap...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Royal Society
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852463/ https://www.ncbi.nlm.nih.gov/pubmed/27249344 http://dx.doi.org/10.1098/rsob.160040 |
| Sumario: | The Mis12 complex forms the central scaffold of the kinetochore and serves to bridge the chromatin and microtubule-binding activities of the inner and outer layers, respectively. Two recent studies provide new structural insights into the formation of this complex, and highlight some intriguing adaptations found in the Drosophila kinetochore. |
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