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Getting to the heart of an unusual kinetochore
The Mis12 complex forms the central scaffold of the kinetochore and serves to bridge the chromatin and microtubule-binding activities of the inner and outer layers, respectively. Two recent studies provide new structural insights into the formation of this complex, and highlight some intriguing adap...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Royal Society
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852463/ https://www.ncbi.nlm.nih.gov/pubmed/27249344 http://dx.doi.org/10.1098/rsob.160040 |
| _version_ | 1782429946369540096 |
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| author | Singleton, Martin R. |
| author_facet | Singleton, Martin R. |
| author_sort | Singleton, Martin R. |
| collection | PubMed |
| description | The Mis12 complex forms the central scaffold of the kinetochore and serves to bridge the chromatin and microtubule-binding activities of the inner and outer layers, respectively. Two recent studies provide new structural insights into the formation of this complex, and highlight some intriguing adaptations found in the Drosophila kinetochore. |
| format | Online Article Text |
| id | pubmed-4852463 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | The Royal Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-48524632016-05-05 Getting to the heart of an unusual kinetochore Singleton, Martin R. Open Biol Comments and Invited Replies The Mis12 complex forms the central scaffold of the kinetochore and serves to bridge the chromatin and microtubule-binding activities of the inner and outer layers, respectively. Two recent studies provide new structural insights into the formation of this complex, and highlight some intriguing adaptations found in the Drosophila kinetochore. The Royal Society 2016-04-13 /pmc/articles/PMC4852463/ /pubmed/27249344 http://dx.doi.org/10.1098/rsob.160040 Text en © 2016 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
| spellingShingle | Comments and Invited Replies Singleton, Martin R. Getting to the heart of an unusual kinetochore |
| title | Getting to the heart of an unusual kinetochore |
| title_full | Getting to the heart of an unusual kinetochore |
| title_fullStr | Getting to the heart of an unusual kinetochore |
| title_full_unstemmed | Getting to the heart of an unusual kinetochore |
| title_short | Getting to the heart of an unusual kinetochore |
| title_sort | getting to the heart of an unusual kinetochore |
| topic | Comments and Invited Replies |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852463/ https://www.ncbi.nlm.nih.gov/pubmed/27249344 http://dx.doi.org/10.1098/rsob.160040 |
| work_keys_str_mv | AT singletonmartinr gettingtotheheartofanunusualkinetochore |