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Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone
The virulence factor mycolactone is responsible for the immunosuppression and tissue necrosis that characterise Buruli ulcer, a disease caused by infection with Mycobacterium ulcerans. In this study, we confirm that Sec61, the protein-conducting channel that coordinates entry of secretory proteins i...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Ltd
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852723/ https://www.ncbi.nlm.nih.gov/pubmed/26869228 http://dx.doi.org/10.1242/jcs.182352 |