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Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof-of-concept and roadmap for future studies
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between schizophrenia cases and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852730/ https://www.ncbi.nlm.nih.gov/pubmed/26854805 http://dx.doi.org/10.1038/nn.4228 |
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| author | Franke, Barbara Stein, Jason L Ripke, Stephan Anttila, Verneri Hibar, Derrek P van Hulzen, Kimm J E Arias-Vasquez, Alejandro Smoller, Jordan W Nichols, Thomas E Neale, Michael C McIntosh, Andrew M Lee, Phil McMahon, Francis J Meyer-Lindenberg, Andreas Mattheisen, Manuel Andreassen, Ole A Gruber, Oliver Sachdev, Perminder S Roiz-Santiañez, Roberto Saykin, Andrew J Ehrlich, Stefan Mather, Karen A Turner, Jessica A Schwarz, Emanuel Thalamuthu, Anbupalam Shugart, Yin Yao Ho, Yvonne YW Martin, Nicholas G Wright, Margaret J O'Donovan, Michael C Thompson, Paul M Neale, Benjamin M Medland, Sarah E Sullivan, Patrick F |
| author_facet | Franke, Barbara Stein, Jason L Ripke, Stephan Anttila, Verneri Hibar, Derrek P van Hulzen, Kimm J E Arias-Vasquez, Alejandro Smoller, Jordan W Nichols, Thomas E Neale, Michael C McIntosh, Andrew M Lee, Phil McMahon, Francis J Meyer-Lindenberg, Andreas Mattheisen, Manuel Andreassen, Ole A Gruber, Oliver Sachdev, Perminder S Roiz-Santiañez, Roberto Saykin, Andrew J Ehrlich, Stefan Mather, Karen A Turner, Jessica A Schwarz, Emanuel Thalamuthu, Anbupalam Shugart, Yin Yao Ho, Yvonne YW Martin, Nicholas G Wright, Margaret J O'Donovan, Michael C Thompson, Paul M Neale, Benjamin M Medland, Sarah E Sullivan, Patrick F |
| author_sort | Franke, Barbara |
| collection | PubMed |
| description | Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between schizophrenia cases and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. The current study provides proof-of-concept (albeit based on a limited set of structural brain measures), and defines a roadmap for future studies investigating the genetic covariance between structural/functional brain phenotypes and risk for psychiatric disorders. |
| format | Online Article Text |
| id | pubmed-4852730 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-48527302016-08-01 Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof-of-concept and roadmap for future studies Franke, Barbara Stein, Jason L Ripke, Stephan Anttila, Verneri Hibar, Derrek P van Hulzen, Kimm J E Arias-Vasquez, Alejandro Smoller, Jordan W Nichols, Thomas E Neale, Michael C McIntosh, Andrew M Lee, Phil McMahon, Francis J Meyer-Lindenberg, Andreas Mattheisen, Manuel Andreassen, Ole A Gruber, Oliver Sachdev, Perminder S Roiz-Santiañez, Roberto Saykin, Andrew J Ehrlich, Stefan Mather, Karen A Turner, Jessica A Schwarz, Emanuel Thalamuthu, Anbupalam Shugart, Yin Yao Ho, Yvonne YW Martin, Nicholas G Wright, Margaret J O'Donovan, Michael C Thompson, Paul M Neale, Benjamin M Medland, Sarah E Sullivan, Patrick F Nat Neurosci Article Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between schizophrenia cases and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. The current study provides proof-of-concept (albeit based on a limited set of structural brain measures), and defines a roadmap for future studies investigating the genetic covariance between structural/functional brain phenotypes and risk for psychiatric disorders. 2016-02-01 2016-03 /pmc/articles/PMC4852730/ /pubmed/26854805 http://dx.doi.org/10.1038/nn.4228 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Franke, Barbara Stein, Jason L Ripke, Stephan Anttila, Verneri Hibar, Derrek P van Hulzen, Kimm J E Arias-Vasquez, Alejandro Smoller, Jordan W Nichols, Thomas E Neale, Michael C McIntosh, Andrew M Lee, Phil McMahon, Francis J Meyer-Lindenberg, Andreas Mattheisen, Manuel Andreassen, Ole A Gruber, Oliver Sachdev, Perminder S Roiz-Santiañez, Roberto Saykin, Andrew J Ehrlich, Stefan Mather, Karen A Turner, Jessica A Schwarz, Emanuel Thalamuthu, Anbupalam Shugart, Yin Yao Ho, Yvonne YW Martin, Nicholas G Wright, Margaret J O'Donovan, Michael C Thompson, Paul M Neale, Benjamin M Medland, Sarah E Sullivan, Patrick F Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof-of-concept and roadmap for future studies |
| title | Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof-of-concept and roadmap for future studies |
| title_full | Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof-of-concept and roadmap for future studies |
| title_fullStr | Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof-of-concept and roadmap for future studies |
| title_full_unstemmed | Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof-of-concept and roadmap for future studies |
| title_short | Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof-of-concept and roadmap for future studies |
| title_sort | genetic influences on schizophrenia and subcortical brain volumes: large-scale proof-of-concept and roadmap for future studies |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852730/ https://www.ncbi.nlm.nih.gov/pubmed/26854805 http://dx.doi.org/10.1038/nn.4228 |
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