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Methods for Efficient Elimination of Mitochondrial DNA from Cultured Cells

Here, we document that persistent mitochondria DNA (mtDNA) damage due to mitochondrial overexpression of the Y147A mutant uracil-N-glycosylase as well as mitochondrial overexpression of bacterial Exonuclease III or Herpes Simplex Virus protein UL12.5M185 can induce a complete loss of mtDNA (ρ(0) phe...

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Detalles Bibliográficos
Autores principales:	Spadafora, Domenico, Kozhukhar, Nataliya, Chouljenko, Vladimir N., Kousoulas, Konstantin G., Alexeyev, Mikhail F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852919/ https://www.ncbi.nlm.nih.gov/pubmed/27136098 http://dx.doi.org/10.1371/journal.pone.0154684

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