Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis

A-kinase anchoring proteins (AKAPs) transmit signals cues from seven-transmembrane receptors to specific sub-cellular locations. Mitochondrial AKAPs encoded by the Akap1 gene have been shown to modulate mitochondrial function and reactive oxygen species (ROS) production in the heart. Under condition...

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Detalles Bibliográficos
Autores principales: Schiattarella, Gabriele Giacomo, Cattaneo, Fabio, Pironti, Gianluigi, Magliulo, Fabio, Carotenuto, Giuseppe, Pirozzi, Marinella, Polishchuk, Roman, Borzacchiello, Domenica, Paolillo, Roberta, Oliveti, Marco, Boccella, Nicola, Avvedimento, Marisa, Sepe, Maria, Lombardi, Assunta, Busiello, Rosa Anna, Trimarco, Bruno, Esposito, Giovanni, Feliciello, Antonio, Perrino, Cinzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852950/
https://www.ncbi.nlm.nih.gov/pubmed/27136357
http://dx.doi.org/10.1371/journal.pone.0154076

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