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Osteoporotic spinal burst fracture in a young adult as first presentation of systemic mastocytosis

Osteoporotic vertebral fractures are uncommon in young adults and usually indicate an underlying disease. Systemic mastocytosis is a myeloproliferative neoplasm, which can be associated with osteoporosis. A previously healthy 30-year-old man presented with an L4 burst fracture after lifting a heavy...

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Autores principales: Ble, Christina, Tsitsopoulos, Parmenion P., Anestis, Dimitrios M., Hadjileontiadou, Sofia, Koletsa, Triantafyllia, Papaioannou, Maria, Tsonidis, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852953/
https://www.ncbi.nlm.nih.gov/pubmed/27141048
http://dx.doi.org/10.1093/jscr/rjw063
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author Ble, Christina
Tsitsopoulos, Parmenion P.
Anestis, Dimitrios M.
Hadjileontiadou, Sofia
Koletsa, Triantafyllia
Papaioannou, Maria
Tsonidis, Christos
author_facet Ble, Christina
Tsitsopoulos, Parmenion P.
Anestis, Dimitrios M.
Hadjileontiadou, Sofia
Koletsa, Triantafyllia
Papaioannou, Maria
Tsonidis, Christos
author_sort Ble, Christina
collection PubMed
description Osteoporotic vertebral fractures are uncommon in young adults and usually indicate an underlying disease. Systemic mastocytosis is a myeloproliferative neoplasm, which can be associated with osteoporosis. A previously healthy 30-year-old man presented with an L4 burst fracture after lifting a heavy object. He was operated with laminectomy and posterior lumbar instrumentation. During surgery, abnormally soft bone was noted. Postoperatively, osteoporosis was confirmed with measurement of bone mineral density. Further investigation revealed elevated serum tryptase levels while bone marrow biopsy findings showed systemic mastocytosis. He was also tested positive for D816V KIT mutation. Treatment with biphosphonates and interferon was initiated. No extraskeletal involvement was noted up to the last checkup, 18 months after the first presentation. Abrupt vertebral fractures in apparently healthy young individuals should raise the suspicion of an underlying pathology. Prompt identification and treatment of systemic mastocytosis is crucial in order to avoid unexpected sequelae.
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spelling pubmed-48529532016-05-03 Osteoporotic spinal burst fracture in a young adult as first presentation of systemic mastocytosis Ble, Christina Tsitsopoulos, Parmenion P. Anestis, Dimitrios M. Hadjileontiadou, Sofia Koletsa, Triantafyllia Papaioannou, Maria Tsonidis, Christos J Surg Case Rep Case Report Osteoporotic vertebral fractures are uncommon in young adults and usually indicate an underlying disease. Systemic mastocytosis is a myeloproliferative neoplasm, which can be associated with osteoporosis. A previously healthy 30-year-old man presented with an L4 burst fracture after lifting a heavy object. He was operated with laminectomy and posterior lumbar instrumentation. During surgery, abnormally soft bone was noted. Postoperatively, osteoporosis was confirmed with measurement of bone mineral density. Further investigation revealed elevated serum tryptase levels while bone marrow biopsy findings showed systemic mastocytosis. He was also tested positive for D816V KIT mutation. Treatment with biphosphonates and interferon was initiated. No extraskeletal involvement was noted up to the last checkup, 18 months after the first presentation. Abrupt vertebral fractures in apparently healthy young individuals should raise the suspicion of an underlying pathology. Prompt identification and treatment of systemic mastocytosis is crucial in order to avoid unexpected sequelae. Oxford University Press 2016-04-30 /pmc/articles/PMC4852953/ /pubmed/27141048 http://dx.doi.org/10.1093/jscr/rjw063 Text en Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author 2016. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Ble, Christina
Tsitsopoulos, Parmenion P.
Anestis, Dimitrios M.
Hadjileontiadou, Sofia
Koletsa, Triantafyllia
Papaioannou, Maria
Tsonidis, Christos
Osteoporotic spinal burst fracture in a young adult as first presentation of systemic mastocytosis
title Osteoporotic spinal burst fracture in a young adult as first presentation of systemic mastocytosis
title_full Osteoporotic spinal burst fracture in a young adult as first presentation of systemic mastocytosis
title_fullStr Osteoporotic spinal burst fracture in a young adult as first presentation of systemic mastocytosis
title_full_unstemmed Osteoporotic spinal burst fracture in a young adult as first presentation of systemic mastocytosis
title_short Osteoporotic spinal burst fracture in a young adult as first presentation of systemic mastocytosis
title_sort osteoporotic spinal burst fracture in a young adult as first presentation of systemic mastocytosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852953/
https://www.ncbi.nlm.nih.gov/pubmed/27141048
http://dx.doi.org/10.1093/jscr/rjw063
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