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Synthesis, characterization, and evaluation of mPEG–SN38 and mPEG–PLA–SN38 micelles for cancer therapy

7-Ethyl-10-hydroxy camptothecin (SN38) is a potent topoisomerase inhibitor and a metabolite of irinotecan. Its clinical development has been hampered by its poor solubility. To address this problem, methoxy poly(ethylene glycol)-2000 (mPEG(2K))–SN38 and mPEG(2K)–poly(lactide) (PLA(1.5K))–SN38 conjug...

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Detalles Bibliográficos
Autores principales:	Xie, Jing, Zhang, Xiaomin, Teng, Meiyu, Yu, Bo, Yang, Shuang, Lee, Robert J, Teng, Lesheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853016/ https://www.ncbi.nlm.nih.gov/pubmed/27217746 http://dx.doi.org/10.2147/IJN.S103110

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