A single flexible RNAPII-CTD integrates many different transcriptional programs

The RNAPII-CTD functions as a binding platform for coordinating the recruitment of transcription associated factors. Altering CTD function results in gene expression defects, although mounting evidence suggests that these effects likely vary among species and loci. Here we highlight emerging evidenc...

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Detalles Bibliográficos
Autores principales: Aristizabal, Maria J., Kobor, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Point-of-View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853039/
https://www.ncbi.nlm.nih.gov/pubmed/26985717
http://dx.doi.org/10.1080/21541264.2016.1163451
Descripción
Sumario:The RNAPII-CTD functions as a binding platform for coordinating the recruitment of transcription associated factors. Altering CTD function results in gene expression defects, although mounting evidence suggests that these effects likely vary among species and loci. Here we highlight emerging evidence of species- and loci-specific functions for the RNAPII-CTD.

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