Long noncoding RNA expression profile analysis of colorectal cancer and metastatic lymph node based on microarray data

Long noncoding RNAs (lncRNAs) are emerging as an important part of biological progress in cancers, yet the aberrant lncRNAs implicated in colorectal cancer (CRC) with lymph node metastasis remain unknown. In this study, a total of 390 lncRNA transcripts and 508 mRNA transcripts were dysregulated in...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Peng, Xu, Zi-Peng, Chen, Tao, He, Zhen-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853163/
https://www.ncbi.nlm.nih.gov/pubmed/27217770
http://dx.doi.org/10.2147/OTT.S102348
_version_ 1782430045616209920
author Yang, Peng
Xu, Zi-Peng
Chen, Tao
He, Zhen-Yu
author_facet Yang, Peng
Xu, Zi-Peng
Chen, Tao
He, Zhen-Yu
author_sort Yang, Peng
collection PubMed
description Long noncoding RNAs (lncRNAs) are emerging as an important part of biological progress in cancers, yet the aberrant lncRNAs implicated in colorectal cancer (CRC) with lymph node metastasis remain unknown. In this study, a total of 390 lncRNA transcripts and 508 mRNA transcripts were dysregulated in tumor tissues compared with paired metastatic lymph nodes. Functional prediction showed that lots of lncRNAs might be involved in biological pathways related to CRC metastasis by cis-regulation and trans-regulation of coexpressed genes. As a representative, ENST00000430471 was associated with cell proliferation and invasion of CRC cells. These results provided support for further investigations of the metastatic pathogenesis of CRC.
format Online
Article
Text
id pubmed-4853163
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-48531632016-05-23 Long noncoding RNA expression profile analysis of colorectal cancer and metastatic lymph node based on microarray data Yang, Peng Xu, Zi-Peng Chen, Tao He, Zhen-Yu Onco Targets Ther Original Research Long noncoding RNAs (lncRNAs) are emerging as an important part of biological progress in cancers, yet the aberrant lncRNAs implicated in colorectal cancer (CRC) with lymph node metastasis remain unknown. In this study, a total of 390 lncRNA transcripts and 508 mRNA transcripts were dysregulated in tumor tissues compared with paired metastatic lymph nodes. Functional prediction showed that lots of lncRNAs might be involved in biological pathways related to CRC metastasis by cis-regulation and trans-regulation of coexpressed genes. As a representative, ENST00000430471 was associated with cell proliferation and invasion of CRC cells. These results provided support for further investigations of the metastatic pathogenesis of CRC. Dove Medical Press 2016-04-26 /pmc/articles/PMC4853163/ /pubmed/27217770 http://dx.doi.org/10.2147/OTT.S102348 Text en © 2016 Yang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Yang, Peng
Xu, Zi-Peng
Chen, Tao
He, Zhen-Yu
Long noncoding RNA expression profile analysis of colorectal cancer and metastatic lymph node based on microarray data
title Long noncoding RNA expression profile analysis of colorectal cancer and metastatic lymph node based on microarray data
title_full Long noncoding RNA expression profile analysis of colorectal cancer and metastatic lymph node based on microarray data
title_fullStr Long noncoding RNA expression profile analysis of colorectal cancer and metastatic lymph node based on microarray data
title_full_unstemmed Long noncoding RNA expression profile analysis of colorectal cancer and metastatic lymph node based on microarray data
title_short Long noncoding RNA expression profile analysis of colorectal cancer and metastatic lymph node based on microarray data
title_sort long noncoding rna expression profile analysis of colorectal cancer and metastatic lymph node based on microarray data
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853163/
https://www.ncbi.nlm.nih.gov/pubmed/27217770
http://dx.doi.org/10.2147/OTT.S102348
work_keys_str_mv AT yangpeng longnoncodingrnaexpressionprofileanalysisofcolorectalcancerandmetastaticlymphnodebasedonmicroarraydata
AT xuzipeng longnoncodingrnaexpressionprofileanalysisofcolorectalcancerandmetastaticlymphnodebasedonmicroarraydata
AT chentao longnoncodingrnaexpressionprofileanalysisofcolorectalcancerandmetastaticlymphnodebasedonmicroarraydata
AT hezhenyu longnoncodingrnaexpressionprofileanalysisofcolorectalcancerandmetastaticlymphnodebasedonmicroarraydata

Ejemplares similares