Cargando…

The NF-κB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma

The REL gene, encoding the NF-κB subunit c-Rel, is frequently amplified in B-cell lymphoma and functions as a tumour-promoting transcription factor. Here we report the surprising result that c-rel–/– mice display significantly earlier lymphomagenesis in the c-Myc driven, Eμ-Myc model of B-cell lymph...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hunter, J E, Butterworth, J A, Zhao, B, Sellier, H, Campbell, K J, Thomas, H D, Bacon, C M, Cockell, S J, Gewurz, B E, Perkins, N D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853301/ https://www.ncbi.nlm.nih.gov/pubmed/26522720 http://dx.doi.org/10.1038/onc.2015.399

Ejemplares similares

A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-κB-dependent liver regeneration and cancer
por: Moles, A, et al.
Publicado: (2016)

Thr(435) phosphorylation regulates RelA (p65) NF-κB subunit transactivation
por: O'Shea, John M., et al.
Publicado: (2010)

Expression and Activity of the NF-κB Subunits in Chronic Lymphocytic Leukaemia: A Role for RelB and Non-Canonical Signalling
por: Mulligan, Evan A., et al.
Publicado: (2023)

Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions
por: Baud, Véronique, et al.
Publicado: (2016)

Regulation of p53 and Rb Links the Alternative NF-κB Pathway to EZH2 Expression and Cell Senescence
por: Iannetti, Alessio, et al.
Publicado: (2014)

NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB
por: Kabacaoglu, Derya, et al.
Publicado: (2019)

Temporal modulation of the NF-κB RelA network in response to different types of DNA damage
por: Campbell, Amy E., et al.
Publicado: (2021)

RelA NF-κB subunit activation as a therapeutic target in diffuse large B-cell lymphoma
por: Zhang, Mingzhi, et al.
Publicado: (2016)

The RelB subunit of NFκB acts as a negative regulator of circadian gene expression
por: Bellet, Marina M., et al.
Publicado: (2012)

Cyclophilin A (CypA) Interacts with NF-κB Subunit, p65/RelA, and Contributes to NF-κB Activation Signaling
por: Sun, Shan, et al.
Publicado: (2014)

The NF-κB RelB Protein Is an Oncogenic Driver of Mesenchymal Glioma
por: Lee, Dong Whan, et al.
Publicado: (2013)

c-Rel Is the Pivotal NF-κB Subunit in Germinal Center Diffuse Large B-Cell Lymphoma: A LYSA Study
por: Faumont, Nathalie, et al.
Publicado: (2021)

Involvement of REL/NF-B Transcription Factors in Cellular Senescence
por: Bernard, David, et al.
Publicado: (2001)

The NF-κB Subunit RelA/p65 Is Dispensable for Successful Liver Regeneration after Partial Hepatectomy in Mice
por: Ringelhan, Marc, et al.
Publicado: (2012)

p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-κB subunit
por: O'Hara, Andrew, et al.
Publicado: (2014)

NF-κB activation by the viral oncoprotein StpC is enhanced by ERK-mediated p52 and RelB upregulation
por: Katsch, K, et al.
Publicado: (2009)

NF-κB/Rel-Mediated Regulation of the Neural Fate in Drosophila
por: Ayyar, Savita, et al.
Publicado: (2007)

Regulation of Immune Responses by NF-κB/Rel Transcription Factors
por: Sha, William C.
Publicado: (1998)

Rel/NF-κB Transcription Factors Emerged at the Onset of Opisthokonts
por: Leger, Michelle M, et al.
Publicado: (2022)

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway
por: Hunter, Jill E., et al.
Publicado: (2022)

P1285: IN VIVO IMPACT OF ABERRANT OVEREXPRESSION OF C-REL NF-ΚB SUBUNIT IN GERMINAL CENTER B-LYMPHOCYTES: A TUMOR ONCOGENIC EVENT IN GCB-DLBCLS
por: Prévaud, L., et al.
Publicado: (2022)

RelB and Neuroinflammation
por: Mockenhaupt, Karli, et al.
Publicado: (2021)

Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice
por: Burkitt, M D, et al.
Publicado: (2013)

c-Rel is a critical mediator of NF-κB-dependent TRAIL resistance of pancreatic cancer cells
por: Geismann, C, et al.
Publicado: (2014)

p50–NF-κB Complexes Partially Compensate for the Absence of RelB: Severely Increased Pathology in p50(−) (/−) relB(−) (/−)Double-knockout Mice
por: Weih, Falk, et al.
Publicado: (1997)

A T cell-intrinsic function for NF-κB RelB in experimental autoimmune encephalomyelitis
por: Lalle, Guilhem, et al.
Publicado: (2021)

Distinct B subunits of PP2A regulate the NF‐κB signalling pathway through dephosphorylation of IKKβ, IκBα and RelA
por: Tsuchiya, Yoshihiro, et al.
Publicado: (2017)

The Alternative RelB NF-kB Subunit Exerts a Critical Survival Function upon Metabolic Stress in Diffuse Large B-Cell Lymphoma-Derived Cells
por: Nuan-Aliman, Stéphanie, et al.
Publicado: (2022)

Cell transformation by v-Rel reveals distinct roles of AP-1 family members in Rel/NF-κB oncogenesis
por: Liss, Andrew S., et al.
Publicado: (2010)

NF-κB Repression by PIAS3 Mediated RelA SUMOylation
por: Liu, Yuangang, et al.
Publicado: (2012)

Foxp3 Interacts with c-Rel to Mediate NF-κB Repression
por: Loizou, Louiza, et al.
Publicado: (2011)

Late-onset Parkinsonism in NFκB/c-Rel-deficient mice
por: Baiguera, Cristina, et al.
Publicado: (2012)

IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer
por: Tsui, Rachel, et al.
Publicado: (2015)

Co-Administration of Molecular Adjuvants Expressing NF-Kappa B Subunit p65/RelA or Type-1 Transactivator T-bet Enhance Antigen Specific DNA Vaccine-Induced Immunity
por: Shedlock, Devon J., et al.
Publicado: (2014)

The Ubiquitination of NF-κB Subunits in the Control of Transcription
por: Collins, Patricia E., et al.
Publicado: (2016)

Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance
por: Hunter, Jill E., et al.
Publicado: (2022)

NFκB regulates expression of Polo-like kinase 4
por: Ledoux, Adeline C, et al.
Publicado: (2013)

c-Rel and its many roles in cancer: an old story with new twists
por: Hunter, Jill E, et al.
Publicado: (2016)

RelB/NF-κB links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis
por: Ge, Qiu-Lin, et al.
Publicado: (2016)

TNF induced inhibition of Cirbp expression depends on RelB NF-κB signalling pathway
por: Lopez, Martin A., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_g2n56hvqbtu6igp3pu8m4v50m7