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Update on the Management of Aspirin-Exacerbated Respiratory Disease
Aspirin-exacerbated respiratory disease (AERD) is an adult-onset upper and lower airway disease consisting of eosinophilic nasal polyps, asthma, and respiratory reactions to cyclooxygenase 1 (COX-1) inhibitors. Management includes guideline-based treatment of asthma and sinus disease, avoidance of C...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853506/ https://www.ncbi.nlm.nih.gov/pubmed/27126722 http://dx.doi.org/10.4168/aair.2016.8.4.298 |
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author | Buchheit, Kathleen M. Laidlaw, Tanya M. |
author_facet | Buchheit, Kathleen M. Laidlaw, Tanya M. |
author_sort | Buchheit, Kathleen M. |
collection | PubMed |
description | Aspirin-exacerbated respiratory disease (AERD) is an adult-onset upper and lower airway disease consisting of eosinophilic nasal polyps, asthma, and respiratory reactions to cyclooxygenase 1 (COX-1) inhibitors. Management includes guideline-based treatment of asthma and sinus disease, avoidance of COX-1 inhibitors, and for some patients aspirin desensitization followed by high-dose aspirin therapy. Despite this, many patients have inadequately controlled symptoms and require multiple sinus surgeries. In this review, we discuss the current standard approaches to the management of AERD, and we introduce several therapeutics under development that may hold promise for the treatment of AERD. |
format | Online Article Text |
id | pubmed-4853506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease |
record_format | MEDLINE/PubMed |
spelling | pubmed-48535062016-07-01 Update on the Management of Aspirin-Exacerbated Respiratory Disease Buchheit, Kathleen M. Laidlaw, Tanya M. Allergy Asthma Immunol Res Review Aspirin-exacerbated respiratory disease (AERD) is an adult-onset upper and lower airway disease consisting of eosinophilic nasal polyps, asthma, and respiratory reactions to cyclooxygenase 1 (COX-1) inhibitors. Management includes guideline-based treatment of asthma and sinus disease, avoidance of COX-1 inhibitors, and for some patients aspirin desensitization followed by high-dose aspirin therapy. Despite this, many patients have inadequately controlled symptoms and require multiple sinus surgeries. In this review, we discuss the current standard approaches to the management of AERD, and we introduce several therapeutics under development that may hold promise for the treatment of AERD. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2016-07 2015-12-08 /pmc/articles/PMC4853506/ /pubmed/27126722 http://dx.doi.org/10.4168/aair.2016.8.4.298 Text en Copyright © 2016 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Buchheit, Kathleen M. Laidlaw, Tanya M. Update on the Management of Aspirin-Exacerbated Respiratory Disease |
title | Update on the Management of Aspirin-Exacerbated Respiratory Disease |
title_full | Update on the Management of Aspirin-Exacerbated Respiratory Disease |
title_fullStr | Update on the Management of Aspirin-Exacerbated Respiratory Disease |
title_full_unstemmed | Update on the Management of Aspirin-Exacerbated Respiratory Disease |
title_short | Update on the Management of Aspirin-Exacerbated Respiratory Disease |
title_sort | update on the management of aspirin-exacerbated respiratory disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853506/ https://www.ncbi.nlm.nih.gov/pubmed/27126722 http://dx.doi.org/10.4168/aair.2016.8.4.298 |
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