Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis

OBJECTIVE: Human leucocyte antigen (HLA)-B27 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly associated with ankylosing spondylitis (AS). ERAP1 is a key aminopeptidase in HLA class I presentation and can potentially alter surface expression of HLA-B27 free heavy chains (FHCs). We stu...

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Detalles Bibliográficos
Autores principales: Chen, Liye, Ridley, Anna, Hammitzsch, Ariane, Al-Mossawi, Mohammad Hussein, Bunting, Helen, Georgiadis, Dimitris, Chan, Antoni, Kollnberger, Simon, Bowness, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853590/
https://www.ncbi.nlm.nih.gov/pubmed/26130142
http://dx.doi.org/10.1136/annrheumdis-2014-206996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853590/
https://www.ncbi.nlm.nih.gov/pubmed/26130142
http://dx.doi.org/10.1136/annrheumdis-2014-206996

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