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Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer

The detection rate of early gastric cancer (EGC) is increasing due to improvements in diagnostic methods, but synchronous multiple EGC (SMEGC) remains a major problem. Therefore, we investigated the characteristics of and the correlation between the main and minor lesions of SMEGC. We retrospectivel...

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Autores principales: Kim, Jung Ho, Jeong, Seok Hoo, Yeo, Jina, Lee, Woon Kee, Chung, Dong Hae, Kim, Kyoung Oh, Chung, Jun-Won, Kim, Yoon Jae, Kwon, Kwang An, Park, Dong Kyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853665/
https://www.ncbi.nlm.nih.gov/pubmed/27247495
http://dx.doi.org/10.3346/jkms.2016.31.6.873
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author Kim, Jung Ho
Jeong, Seok Hoo
Yeo, Jina
Lee, Woon Kee
Chung, Dong Hae
Kim, Kyoung Oh
Chung, Jun-Won
Kim, Yoon Jae
Kwon, Kwang An
Park, Dong Kyun
author_facet Kim, Jung Ho
Jeong, Seok Hoo
Yeo, Jina
Lee, Woon Kee
Chung, Dong Hae
Kim, Kyoung Oh
Chung, Jun-Won
Kim, Yoon Jae
Kwon, Kwang An
Park, Dong Kyun
author_sort Kim, Jung Ho
collection PubMed
description The detection rate of early gastric cancer (EGC) is increasing due to improvements in diagnostic methods, but synchronous multiple EGC (SMEGC) remains a major problem. Therefore, we investigated the characteristics of and the correlation between the main and minor lesions of SMEGC. We retrospectively reviewed the medical records of patients with EGC between April 2008 and May 2013. The main lesion was defined as the one with the greatest invasion depth. If lesions had the same invasion depth, the tumor diameter was used to define the main lesion. Of 963 patients who had treatment for EGC, 37 patients with SMEGC were analyzed. The main and minor lesions showed a significant positive correlation of size (r = 0.533, P = 0.001). The main and minor lesions of SMEGC showed the same vertical and horizontal locations at 70.3% and 64.9%, respectively (P = 0.002 and P = 0.002). Macroscopic types were identical in 67.6% (P < 0.001), and 32.4% had identical macroscopic type and location. The main and minor lesions had identical characteristics of invasion depth, presence of lymphovascular invasion (LVI), and differentiation in 78.4%, 83.8%, and 83.8%, respectively. Differentiation, LVI, and invasion depth (microscopic characteristics) were simultaneously the same in 62.2%. The location, macroscopic type, and 3 microscopic characteristics were matched in 27%. The main and minor lesions of SMEGC have similar clinicopathologic characteristics. Therefore, the possibility of SMEGC should not be neglected in cases of EGC, considering an understanding of the characteristics and association of lesions.
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spelling pubmed-48536652016-06-01 Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer Kim, Jung Ho Jeong, Seok Hoo Yeo, Jina Lee, Woon Kee Chung, Dong Hae Kim, Kyoung Oh Chung, Jun-Won Kim, Yoon Jae Kwon, Kwang An Park, Dong Kyun J Korean Med Sci Original Article The detection rate of early gastric cancer (EGC) is increasing due to improvements in diagnostic methods, but synchronous multiple EGC (SMEGC) remains a major problem. Therefore, we investigated the characteristics of and the correlation between the main and minor lesions of SMEGC. We retrospectively reviewed the medical records of patients with EGC between April 2008 and May 2013. The main lesion was defined as the one with the greatest invasion depth. If lesions had the same invasion depth, the tumor diameter was used to define the main lesion. Of 963 patients who had treatment for EGC, 37 patients with SMEGC were analyzed. The main and minor lesions showed a significant positive correlation of size (r = 0.533, P = 0.001). The main and minor lesions of SMEGC showed the same vertical and horizontal locations at 70.3% and 64.9%, respectively (P = 0.002 and P = 0.002). Macroscopic types were identical in 67.6% (P < 0.001), and 32.4% had identical macroscopic type and location. The main and minor lesions had identical characteristics of invasion depth, presence of lymphovascular invasion (LVI), and differentiation in 78.4%, 83.8%, and 83.8%, respectively. Differentiation, LVI, and invasion depth (microscopic characteristics) were simultaneously the same in 62.2%. The location, macroscopic type, and 3 microscopic characteristics were matched in 27%. The main and minor lesions of SMEGC have similar clinicopathologic characteristics. Therefore, the possibility of SMEGC should not be neglected in cases of EGC, considering an understanding of the characteristics and association of lesions. The Korean Academy of Medical Sciences 2016-06 2016-04-15 /pmc/articles/PMC4853665/ /pubmed/27247495 http://dx.doi.org/10.3346/jkms.2016.31.6.873 Text en © 2016 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Jung Ho
Jeong, Seok Hoo
Yeo, Jina
Lee, Woon Kee
Chung, Dong Hae
Kim, Kyoung Oh
Chung, Jun-Won
Kim, Yoon Jae
Kwon, Kwang An
Park, Dong Kyun
Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer
title Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer
title_full Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer
title_fullStr Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer
title_full_unstemmed Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer
title_short Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer
title_sort clinicopathologic similarities of the main and minor lesions of synchronous multiple early gastric cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853665/
https://www.ncbi.nlm.nih.gov/pubmed/27247495
http://dx.doi.org/10.3346/jkms.2016.31.6.873
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