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Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer
The detection rate of early gastric cancer (EGC) is increasing due to improvements in diagnostic methods, but synchronous multiple EGC (SMEGC) remains a major problem. Therefore, we investigated the characteristics of and the correlation between the main and minor lesions of SMEGC. We retrospectivel...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853665/ https://www.ncbi.nlm.nih.gov/pubmed/27247495 http://dx.doi.org/10.3346/jkms.2016.31.6.873 |
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author | Kim, Jung Ho Jeong, Seok Hoo Yeo, Jina Lee, Woon Kee Chung, Dong Hae Kim, Kyoung Oh Chung, Jun-Won Kim, Yoon Jae Kwon, Kwang An Park, Dong Kyun |
author_facet | Kim, Jung Ho Jeong, Seok Hoo Yeo, Jina Lee, Woon Kee Chung, Dong Hae Kim, Kyoung Oh Chung, Jun-Won Kim, Yoon Jae Kwon, Kwang An Park, Dong Kyun |
author_sort | Kim, Jung Ho |
collection | PubMed |
description | The detection rate of early gastric cancer (EGC) is increasing due to improvements in diagnostic methods, but synchronous multiple EGC (SMEGC) remains a major problem. Therefore, we investigated the characteristics of and the correlation between the main and minor lesions of SMEGC. We retrospectively reviewed the medical records of patients with EGC between April 2008 and May 2013. The main lesion was defined as the one with the greatest invasion depth. If lesions had the same invasion depth, the tumor diameter was used to define the main lesion. Of 963 patients who had treatment for EGC, 37 patients with SMEGC were analyzed. The main and minor lesions showed a significant positive correlation of size (r = 0.533, P = 0.001). The main and minor lesions of SMEGC showed the same vertical and horizontal locations at 70.3% and 64.9%, respectively (P = 0.002 and P = 0.002). Macroscopic types were identical in 67.6% (P < 0.001), and 32.4% had identical macroscopic type and location. The main and minor lesions had identical characteristics of invasion depth, presence of lymphovascular invasion (LVI), and differentiation in 78.4%, 83.8%, and 83.8%, respectively. Differentiation, LVI, and invasion depth (microscopic characteristics) were simultaneously the same in 62.2%. The location, macroscopic type, and 3 microscopic characteristics were matched in 27%. The main and minor lesions of SMEGC have similar clinicopathologic characteristics. Therefore, the possibility of SMEGC should not be neglected in cases of EGC, considering an understanding of the characteristics and association of lesions. |
format | Online Article Text |
id | pubmed-4853665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-48536652016-06-01 Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer Kim, Jung Ho Jeong, Seok Hoo Yeo, Jina Lee, Woon Kee Chung, Dong Hae Kim, Kyoung Oh Chung, Jun-Won Kim, Yoon Jae Kwon, Kwang An Park, Dong Kyun J Korean Med Sci Original Article The detection rate of early gastric cancer (EGC) is increasing due to improvements in diagnostic methods, but synchronous multiple EGC (SMEGC) remains a major problem. Therefore, we investigated the characteristics of and the correlation between the main and minor lesions of SMEGC. We retrospectively reviewed the medical records of patients with EGC between April 2008 and May 2013. The main lesion was defined as the one with the greatest invasion depth. If lesions had the same invasion depth, the tumor diameter was used to define the main lesion. Of 963 patients who had treatment for EGC, 37 patients with SMEGC were analyzed. The main and minor lesions showed a significant positive correlation of size (r = 0.533, P = 0.001). The main and minor lesions of SMEGC showed the same vertical and horizontal locations at 70.3% and 64.9%, respectively (P = 0.002 and P = 0.002). Macroscopic types were identical in 67.6% (P < 0.001), and 32.4% had identical macroscopic type and location. The main and minor lesions had identical characteristics of invasion depth, presence of lymphovascular invasion (LVI), and differentiation in 78.4%, 83.8%, and 83.8%, respectively. Differentiation, LVI, and invasion depth (microscopic characteristics) were simultaneously the same in 62.2%. The location, macroscopic type, and 3 microscopic characteristics were matched in 27%. The main and minor lesions of SMEGC have similar clinicopathologic characteristics. Therefore, the possibility of SMEGC should not be neglected in cases of EGC, considering an understanding of the characteristics and association of lesions. The Korean Academy of Medical Sciences 2016-06 2016-04-15 /pmc/articles/PMC4853665/ /pubmed/27247495 http://dx.doi.org/10.3346/jkms.2016.31.6.873 Text en © 2016 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Jung Ho Jeong, Seok Hoo Yeo, Jina Lee, Woon Kee Chung, Dong Hae Kim, Kyoung Oh Chung, Jun-Won Kim, Yoon Jae Kwon, Kwang An Park, Dong Kyun Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer |
title | Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer |
title_full | Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer |
title_fullStr | Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer |
title_full_unstemmed | Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer |
title_short | Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer |
title_sort | clinicopathologic similarities of the main and minor lesions of synchronous multiple early gastric cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853665/ https://www.ncbi.nlm.nih.gov/pubmed/27247495 http://dx.doi.org/10.3346/jkms.2016.31.6.873 |
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