Cargando…

Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection

This study aimed to evaluate the association between body mass index (BMI) and progression in triple-negative breast cancer (TNBC). We retrospectively reviewed the medical records of 50 patients with TNBC who underwent breast-conserving surgery or mastectomy between 2007 and 2014. All patients were...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Yunseon, Park, Sung Kwang, Ahn, Ki Jung, Cho, Heunglae, Kim, Tae Hyun, Yoon, Hye Kyoung, Lee, Yun-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853667/
https://www.ncbi.nlm.nih.gov/pubmed/27247497
http://dx.doi.org/10.3346/jkms.2016.31.6.886
_version_ 1782430105366167552
author Choi, Yunseon
Park, Sung Kwang
Ahn, Ki Jung
Cho, Heunglae
Kim, Tae Hyun
Yoon, Hye Kyoung
Lee, Yun-Han
author_facet Choi, Yunseon
Park, Sung Kwang
Ahn, Ki Jung
Cho, Heunglae
Kim, Tae Hyun
Yoon, Hye Kyoung
Lee, Yun-Han
author_sort Choi, Yunseon
collection PubMed
description This study aimed to evaluate the association between body mass index (BMI) and progression in triple-negative breast cancer (TNBC). We retrospectively reviewed the medical records of 50 patients with TNBC who underwent breast-conserving surgery or mastectomy between 2007 and 2014. All patients were classified according to BMI (median 23.5 kg/m(2), range 17.2–31.6 kg/m(2)): 31 patients (62%) were classified as being overweight or obese (BMI ≥ 23 kg/m(2)) and 19 patients (38%) were classified as having a normal body weight (BMI < 23 kg/m(2)). The median follow-up for patients was 31.1 months (range, 6.7–101.9 months). Progression occurred in 7 patients (14%), including 5 ipsilateral breast tumor recurrences, 2 regional lymph node metastases, and 5 distant metastases. Progression was significantly correlated with overweight or obese patients (P = 0.035), while none of the normal weight patients showed progression. The 3-year disease-free survival (DFS) and overall survival (OS) rates were 85.0% and 87.7%, respectively. DFS was significantly reduced in overweight or obese patients compared to that in normal weight patients (P = 0.035). However, OS was not significantly compromised by being overweight or obese (P = 0.134). In conclusion, being overweight or obese negatively affects DFS in TNBC patients.
format Online
Article
Text
id pubmed-4853667
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher The Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-48536672016-06-01 Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection Choi, Yunseon Park, Sung Kwang Ahn, Ki Jung Cho, Heunglae Kim, Tae Hyun Yoon, Hye Kyoung Lee, Yun-Han J Korean Med Sci Original Article This study aimed to evaluate the association between body mass index (BMI) and progression in triple-negative breast cancer (TNBC). We retrospectively reviewed the medical records of 50 patients with TNBC who underwent breast-conserving surgery or mastectomy between 2007 and 2014. All patients were classified according to BMI (median 23.5 kg/m(2), range 17.2–31.6 kg/m(2)): 31 patients (62%) were classified as being overweight or obese (BMI ≥ 23 kg/m(2)) and 19 patients (38%) were classified as having a normal body weight (BMI < 23 kg/m(2)). The median follow-up for patients was 31.1 months (range, 6.7–101.9 months). Progression occurred in 7 patients (14%), including 5 ipsilateral breast tumor recurrences, 2 regional lymph node metastases, and 5 distant metastases. Progression was significantly correlated with overweight or obese patients (P = 0.035), while none of the normal weight patients showed progression. The 3-year disease-free survival (DFS) and overall survival (OS) rates were 85.0% and 87.7%, respectively. DFS was significantly reduced in overweight or obese patients compared to that in normal weight patients (P = 0.035). However, OS was not significantly compromised by being overweight or obese (P = 0.134). In conclusion, being overweight or obese negatively affects DFS in TNBC patients. The Korean Academy of Medical Sciences 2016-06 2016-04-22 /pmc/articles/PMC4853667/ /pubmed/27247497 http://dx.doi.org/10.3346/jkms.2016.31.6.886 Text en © 2016 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Choi, Yunseon
Park, Sung Kwang
Ahn, Ki Jung
Cho, Heunglae
Kim, Tae Hyun
Yoon, Hye Kyoung
Lee, Yun-Han
Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection
title Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection
title_full Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection
title_fullStr Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection
title_full_unstemmed Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection
title_short Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection
title_sort being overweight or obese increases the risk of progression in triple-negative breast cancer after surgical resection
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853667/
https://www.ncbi.nlm.nih.gov/pubmed/27247497
http://dx.doi.org/10.3346/jkms.2016.31.6.886
work_keys_str_mv AT choiyunseon beingoverweightorobeseincreasestheriskofprogressionintriplenegativebreastcanceraftersurgicalresection
AT parksungkwang beingoverweightorobeseincreasestheriskofprogressionintriplenegativebreastcanceraftersurgicalresection
AT ahnkijung beingoverweightorobeseincreasestheriskofprogressionintriplenegativebreastcanceraftersurgicalresection
AT choheunglae beingoverweightorobeseincreasestheriskofprogressionintriplenegativebreastcanceraftersurgicalresection
AT kimtaehyun beingoverweightorobeseincreasestheriskofprogressionintriplenegativebreastcanceraftersurgicalresection
AT yoonhyekyoung beingoverweightorobeseincreasestheriskofprogressionintriplenegativebreastcanceraftersurgicalresection
AT leeyunhan beingoverweightorobeseincreasestheriskofprogressionintriplenegativebreastcanceraftersurgicalresection