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Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection
This study aimed to evaluate the association between body mass index (BMI) and progression in triple-negative breast cancer (TNBC). We retrospectively reviewed the medical records of 50 patients with TNBC who underwent breast-conserving surgery or mastectomy between 2007 and 2014. All patients were...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Academy of Medical Sciences
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853667/ https://www.ncbi.nlm.nih.gov/pubmed/27247497 http://dx.doi.org/10.3346/jkms.2016.31.6.886 |
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author | Choi, Yunseon Park, Sung Kwang Ahn, Ki Jung Cho, Heunglae Kim, Tae Hyun Yoon, Hye Kyoung Lee, Yun-Han |
author_facet | Choi, Yunseon Park, Sung Kwang Ahn, Ki Jung Cho, Heunglae Kim, Tae Hyun Yoon, Hye Kyoung Lee, Yun-Han |
author_sort | Choi, Yunseon |
collection | PubMed |
description | This study aimed to evaluate the association between body mass index (BMI) and progression in triple-negative breast cancer (TNBC). We retrospectively reviewed the medical records of 50 patients with TNBC who underwent breast-conserving surgery or mastectomy between 2007 and 2014. All patients were classified according to BMI (median 23.5 kg/m(2), range 17.2–31.6 kg/m(2)): 31 patients (62%) were classified as being overweight or obese (BMI ≥ 23 kg/m(2)) and 19 patients (38%) were classified as having a normal body weight (BMI < 23 kg/m(2)). The median follow-up for patients was 31.1 months (range, 6.7–101.9 months). Progression occurred in 7 patients (14%), including 5 ipsilateral breast tumor recurrences, 2 regional lymph node metastases, and 5 distant metastases. Progression was significantly correlated with overweight or obese patients (P = 0.035), while none of the normal weight patients showed progression. The 3-year disease-free survival (DFS) and overall survival (OS) rates were 85.0% and 87.7%, respectively. DFS was significantly reduced in overweight or obese patients compared to that in normal weight patients (P = 0.035). However, OS was not significantly compromised by being overweight or obese (P = 0.134). In conclusion, being overweight or obese negatively affects DFS in TNBC patients. |
format | Online Article Text |
id | pubmed-4853667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-48536672016-06-01 Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection Choi, Yunseon Park, Sung Kwang Ahn, Ki Jung Cho, Heunglae Kim, Tae Hyun Yoon, Hye Kyoung Lee, Yun-Han J Korean Med Sci Original Article This study aimed to evaluate the association between body mass index (BMI) and progression in triple-negative breast cancer (TNBC). We retrospectively reviewed the medical records of 50 patients with TNBC who underwent breast-conserving surgery or mastectomy between 2007 and 2014. All patients were classified according to BMI (median 23.5 kg/m(2), range 17.2–31.6 kg/m(2)): 31 patients (62%) were classified as being overweight or obese (BMI ≥ 23 kg/m(2)) and 19 patients (38%) were classified as having a normal body weight (BMI < 23 kg/m(2)). The median follow-up for patients was 31.1 months (range, 6.7–101.9 months). Progression occurred in 7 patients (14%), including 5 ipsilateral breast tumor recurrences, 2 regional lymph node metastases, and 5 distant metastases. Progression was significantly correlated with overweight or obese patients (P = 0.035), while none of the normal weight patients showed progression. The 3-year disease-free survival (DFS) and overall survival (OS) rates were 85.0% and 87.7%, respectively. DFS was significantly reduced in overweight or obese patients compared to that in normal weight patients (P = 0.035). However, OS was not significantly compromised by being overweight or obese (P = 0.134). In conclusion, being overweight or obese negatively affects DFS in TNBC patients. The Korean Academy of Medical Sciences 2016-06 2016-04-22 /pmc/articles/PMC4853667/ /pubmed/27247497 http://dx.doi.org/10.3346/jkms.2016.31.6.886 Text en © 2016 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Choi, Yunseon Park, Sung Kwang Ahn, Ki Jung Cho, Heunglae Kim, Tae Hyun Yoon, Hye Kyoung Lee, Yun-Han Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection |
title | Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection |
title_full | Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection |
title_fullStr | Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection |
title_full_unstemmed | Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection |
title_short | Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection |
title_sort | being overweight or obese increases the risk of progression in triple-negative breast cancer after surgical resection |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853667/ https://www.ncbi.nlm.nih.gov/pubmed/27247497 http://dx.doi.org/10.3346/jkms.2016.31.6.886 |
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