Cargando…

Role of Coronary Artery Calcium Scoring in Detection of Coronary Artery Disease according to Framingham Risk Score in Populations with Low to Intermediate Risks

Current guidelines recommend that coronary artery calcium (CAC) screening should only be used for intermediate risk groups (Framingham risk score [FRS] of 10%–20%). The CAC distributions and coronary artery disease (CAD) prevalence in various FRS strata were determined. The benefit to lower risk pop...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Won-Jang, Kwon, Chang Hee, Han, Seungbong, Lee, Woo Seok, Kang, Joon Won, Ahn, Jung-Min, Lee, Jong-Young, Park, Duk-Woo, Kang, Soo-Jin, Lee, Seung-Whan, Kim, Young-Hak, Lee, Cheol Whan, Park, Seong-Wook, Park, Seung-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853669/
https://www.ncbi.nlm.nih.gov/pubmed/27247499
http://dx.doi.org/10.3346/jkms.2016.31.6.902
_version_ 1782430105847463936
author Kim, Won-Jang
Kwon, Chang Hee
Han, Seungbong
Lee, Woo Seok
Kang, Joon Won
Ahn, Jung-Min
Lee, Jong-Young
Park, Duk-Woo
Kang, Soo-Jin
Lee, Seung-Whan
Kim, Young-Hak
Lee, Cheol Whan
Park, Seong-Wook
Park, Seung-Jung
author_facet Kim, Won-Jang
Kwon, Chang Hee
Han, Seungbong
Lee, Woo Seok
Kang, Joon Won
Ahn, Jung-Min
Lee, Jong-Young
Park, Duk-Woo
Kang, Soo-Jin
Lee, Seung-Whan
Kim, Young-Hak
Lee, Cheol Whan
Park, Seong-Wook
Park, Seung-Jung
author_sort Kim, Won-Jang
collection PubMed
description Current guidelines recommend that coronary artery calcium (CAC) screening should only be used for intermediate risk groups (Framingham risk score [FRS] of 10%–20%). The CAC distributions and coronary artery disease (CAD) prevalence in various FRS strata were determined. The benefit to lower risk populations of CAC score-based screening was also assessed. In total, 1,854 participants (aged 40–79 years) without history of CAD, stroke, or diabetes were enrolled. CAC scores of > 0, ≥ 100, and ≥ 300 were present in 33.8%, 8.2%, and 2.9% of the participants, respectively. The CAC scores rose significantly as the FRS grew more severe (P < 0.01). The total CAD prevalence was 6.1%. The occult CAD prevalence in the FRS ≤ 5%, 6%–10%, 11%–20%, and > 20% strata were 3.4%, 6.7%, 9.0%, and 11.6% (P < 0.001). In multivariate logistic regression analysis adjusting, not only the intermediate and high risk groups but also the low risk (FRS 6%–10%) group had significantly increased odds ratio for occult CAD compared to the very low-risk (FRS ≤ 5%) group (1.89 [95% confidence interval, CI, 1.09–3.29] in FRS 6%–10%; 2.48 [95% CI, 1.47–4.20] in FRS 11%–20%; and 3.10 [95% CI, 1.75–5.47] in FRS > 20%; P < 0.05). In conclusion, the yield of screening for significant CAC and occult CAD is low in the very low risk population but it rises in low and intermediate risk populations.
format Online
Article
Text
id pubmed-4853669
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher The Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-48536692016-06-01 Role of Coronary Artery Calcium Scoring in Detection of Coronary Artery Disease according to Framingham Risk Score in Populations with Low to Intermediate Risks Kim, Won-Jang Kwon, Chang Hee Han, Seungbong Lee, Woo Seok Kang, Joon Won Ahn, Jung-Min Lee, Jong-Young Park, Duk-Woo Kang, Soo-Jin Lee, Seung-Whan Kim, Young-Hak Lee, Cheol Whan Park, Seong-Wook Park, Seung-Jung J Korean Med Sci Original Article Current guidelines recommend that coronary artery calcium (CAC) screening should only be used for intermediate risk groups (Framingham risk score [FRS] of 10%–20%). The CAC distributions and coronary artery disease (CAD) prevalence in various FRS strata were determined. The benefit to lower risk populations of CAC score-based screening was also assessed. In total, 1,854 participants (aged 40–79 years) without history of CAD, stroke, or diabetes were enrolled. CAC scores of > 0, ≥ 100, and ≥ 300 were present in 33.8%, 8.2%, and 2.9% of the participants, respectively. The CAC scores rose significantly as the FRS grew more severe (P < 0.01). The total CAD prevalence was 6.1%. The occult CAD prevalence in the FRS ≤ 5%, 6%–10%, 11%–20%, and > 20% strata were 3.4%, 6.7%, 9.0%, and 11.6% (P < 0.001). In multivariate logistic regression analysis adjusting, not only the intermediate and high risk groups but also the low risk (FRS 6%–10%) group had significantly increased odds ratio for occult CAD compared to the very low-risk (FRS ≤ 5%) group (1.89 [95% confidence interval, CI, 1.09–3.29] in FRS 6%–10%; 2.48 [95% CI, 1.47–4.20] in FRS 11%–20%; and 3.10 [95% CI, 1.75–5.47] in FRS > 20%; P < 0.05). In conclusion, the yield of screening for significant CAC and occult CAD is low in the very low risk population but it rises in low and intermediate risk populations. The Korean Academy of Medical Sciences 2016-06 2016-04-18 /pmc/articles/PMC4853669/ /pubmed/27247499 http://dx.doi.org/10.3346/jkms.2016.31.6.902 Text en © 2016 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Won-Jang
Kwon, Chang Hee
Han, Seungbong
Lee, Woo Seok
Kang, Joon Won
Ahn, Jung-Min
Lee, Jong-Young
Park, Duk-Woo
Kang, Soo-Jin
Lee, Seung-Whan
Kim, Young-Hak
Lee, Cheol Whan
Park, Seong-Wook
Park, Seung-Jung
Role of Coronary Artery Calcium Scoring in Detection of Coronary Artery Disease according to Framingham Risk Score in Populations with Low to Intermediate Risks
title Role of Coronary Artery Calcium Scoring in Detection of Coronary Artery Disease according to Framingham Risk Score in Populations with Low to Intermediate Risks
title_full Role of Coronary Artery Calcium Scoring in Detection of Coronary Artery Disease according to Framingham Risk Score in Populations with Low to Intermediate Risks
title_fullStr Role of Coronary Artery Calcium Scoring in Detection of Coronary Artery Disease according to Framingham Risk Score in Populations with Low to Intermediate Risks
title_full_unstemmed Role of Coronary Artery Calcium Scoring in Detection of Coronary Artery Disease according to Framingham Risk Score in Populations with Low to Intermediate Risks
title_short Role of Coronary Artery Calcium Scoring in Detection of Coronary Artery Disease according to Framingham Risk Score in Populations with Low to Intermediate Risks
title_sort role of coronary artery calcium scoring in detection of coronary artery disease according to framingham risk score in populations with low to intermediate risks
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853669/
https://www.ncbi.nlm.nih.gov/pubmed/27247499
http://dx.doi.org/10.3346/jkms.2016.31.6.902
work_keys_str_mv AT kimwonjang roleofcoronaryarterycalciumscoringindetectionofcoronaryarterydiseaseaccordingtoframinghamriskscoreinpopulationswithlowtointermediaterisks
AT kwonchanghee roleofcoronaryarterycalciumscoringindetectionofcoronaryarterydiseaseaccordingtoframinghamriskscoreinpopulationswithlowtointermediaterisks
AT hanseungbong roleofcoronaryarterycalciumscoringindetectionofcoronaryarterydiseaseaccordingtoframinghamriskscoreinpopulationswithlowtointermediaterisks
AT leewooseok roleofcoronaryarterycalciumscoringindetectionofcoronaryarterydiseaseaccordingtoframinghamriskscoreinpopulationswithlowtointermediaterisks
AT kangjoonwon roleofcoronaryarterycalciumscoringindetectionofcoronaryarterydiseaseaccordingtoframinghamriskscoreinpopulationswithlowtointermediaterisks
AT ahnjungmin roleofcoronaryarterycalciumscoringindetectionofcoronaryarterydiseaseaccordingtoframinghamriskscoreinpopulationswithlowtointermediaterisks
AT leejongyoung roleofcoronaryarterycalciumscoringindetectionofcoronaryarterydiseaseaccordingtoframinghamriskscoreinpopulationswithlowtointermediaterisks
AT parkdukwoo roleofcoronaryarterycalciumscoringindetectionofcoronaryarterydiseaseaccordingtoframinghamriskscoreinpopulationswithlowtointermediaterisks
AT kangsoojin roleofcoronaryarterycalciumscoringindetectionofcoronaryarterydiseaseaccordingtoframinghamriskscoreinpopulationswithlowtointermediaterisks
AT leeseungwhan roleofcoronaryarterycalciumscoringindetectionofcoronaryarterydiseaseaccordingtoframinghamriskscoreinpopulationswithlowtointermediaterisks
AT kimyounghak roleofcoronaryarterycalciumscoringindetectionofcoronaryarterydiseaseaccordingtoframinghamriskscoreinpopulationswithlowtointermediaterisks
AT leecheolwhan roleofcoronaryarterycalciumscoringindetectionofcoronaryarterydiseaseaccordingtoframinghamriskscoreinpopulationswithlowtointermediaterisks
AT parkseongwook roleofcoronaryarterycalciumscoringindetectionofcoronaryarterydiseaseaccordingtoframinghamriskscoreinpopulationswithlowtointermediaterisks
AT parkseungjung roleofcoronaryarterycalciumscoringindetectionofcoronaryarterydiseaseaccordingtoframinghamriskscoreinpopulationswithlowtointermediaterisks