A gain-of-function ACTC1 3′UTR mutation that introduces a miR-139-5p target site may be associated with a dominant familial atrial septal defect

The ostium secundum atrial septal defect (ASDII) is the most common type of congenital heart disease and is characterized by a left to right shunting of oxygenated blood caused by incomplete closure of the septum secundum. We identified a familial form of isolated ASDII that affects four individuals...

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Detalles Bibliográficos
Autores principales: Wang, Ye, Du, Xinwei, Zhou, Zaiwei, Jiang, Jun, Zhang, Zhen, Ye, Lincai, Hong, Haifa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853704/
https://www.ncbi.nlm.nih.gov/pubmed/27139165
http://dx.doi.org/10.1038/srep25404

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