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New Hosts of The Lassa Virus
Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to be the sole host of LASV. We found evidence that LASV is also hosted by other rodent species: t...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853722/ https://www.ncbi.nlm.nih.gov/pubmed/27140942 http://dx.doi.org/10.1038/srep25280 |
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| author | Olayemi, Ayodeji Cadar, Daniel Magassouba, N’Faly Obadare, Adeoba Kourouma, Fode Oyeyiola, Akinlabi Fasogbon, Samuel Igbokwe, Joseph Rieger, Toni Bockholt, Sabrina Jérôme, Hanna Schmidt-Chanasit, Jonas Garigliany, Mutien Lorenzen, Stephan Igbahenah, Felix Fichet, Jean-Nicolas Ortsega, Daniel Omilabu, Sunday Günther, Stephan Fichet-Calvet, Elisabeth |
| author_facet | Olayemi, Ayodeji Cadar, Daniel Magassouba, N’Faly Obadare, Adeoba Kourouma, Fode Oyeyiola, Akinlabi Fasogbon, Samuel Igbokwe, Joseph Rieger, Toni Bockholt, Sabrina Jérôme, Hanna Schmidt-Chanasit, Jonas Garigliany, Mutien Lorenzen, Stephan Igbahenah, Felix Fichet, Jean-Nicolas Ortsega, Daniel Omilabu, Sunday Günther, Stephan Fichet-Calvet, Elisabeth |
| author_sort | Olayemi, Ayodeji |
| collection | PubMed |
| description | Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to be the sole host of LASV. We found evidence that LASV is also hosted by other rodent species: the African wood mouse Hylomyscus pamfi in Nigeria, and the Guinea multimammate mouse Mastomys erythroleucus in both Nigeria and Guinea. Virus strains from these animals were isolated in the BSL-4 laboratory and fully sequenced. Phylogenetic analyses of viral genes coding for glycoprotein, nucleoprotein, polymerase and matrix protein show that Lassa strains detected in M. erythroleucus belong to lineages III and IV. The strain from H. pamfi clusters close to lineage I (for S gene) and between II & III (for L gene). Discovery of new rodent hosts has implications for LASV evolution and its spread into new areas within West Africa. |
| format | Online Article Text |
| id | pubmed-4853722 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-48537222016-05-16 New Hosts of The Lassa Virus Olayemi, Ayodeji Cadar, Daniel Magassouba, N’Faly Obadare, Adeoba Kourouma, Fode Oyeyiola, Akinlabi Fasogbon, Samuel Igbokwe, Joseph Rieger, Toni Bockholt, Sabrina Jérôme, Hanna Schmidt-Chanasit, Jonas Garigliany, Mutien Lorenzen, Stephan Igbahenah, Felix Fichet, Jean-Nicolas Ortsega, Daniel Omilabu, Sunday Günther, Stephan Fichet-Calvet, Elisabeth Sci Rep Article Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to be the sole host of LASV. We found evidence that LASV is also hosted by other rodent species: the African wood mouse Hylomyscus pamfi in Nigeria, and the Guinea multimammate mouse Mastomys erythroleucus in both Nigeria and Guinea. Virus strains from these animals were isolated in the BSL-4 laboratory and fully sequenced. Phylogenetic analyses of viral genes coding for glycoprotein, nucleoprotein, polymerase and matrix protein show that Lassa strains detected in M. erythroleucus belong to lineages III and IV. The strain from H. pamfi clusters close to lineage I (for S gene) and between II & III (for L gene). Discovery of new rodent hosts has implications for LASV evolution and its spread into new areas within West Africa. Nature Publishing Group 2016-05-03 /pmc/articles/PMC4853722/ /pubmed/27140942 http://dx.doi.org/10.1038/srep25280 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Olayemi, Ayodeji Cadar, Daniel Magassouba, N’Faly Obadare, Adeoba Kourouma, Fode Oyeyiola, Akinlabi Fasogbon, Samuel Igbokwe, Joseph Rieger, Toni Bockholt, Sabrina Jérôme, Hanna Schmidt-Chanasit, Jonas Garigliany, Mutien Lorenzen, Stephan Igbahenah, Felix Fichet, Jean-Nicolas Ortsega, Daniel Omilabu, Sunday Günther, Stephan Fichet-Calvet, Elisabeth New Hosts of The Lassa Virus |
| title | New Hosts of The Lassa Virus |
| title_full | New Hosts of The Lassa Virus |
| title_fullStr | New Hosts of The Lassa Virus |
| title_full_unstemmed | New Hosts of The Lassa Virus |
| title_short | New Hosts of The Lassa Virus |
| title_sort | new hosts of the lassa virus |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853722/ https://www.ncbi.nlm.nih.gov/pubmed/27140942 http://dx.doi.org/10.1038/srep25280 |
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