A CRISPR-based approach for targeted DNA demethylation

In mammalian cells, DNA methylation critically regulates gene expression and thus has pivotal roles in myriad of physiological and pathological processes. Here we report a novel method for targeted DNA demethylation using the widely used clustered regularly interspaced short palindromic repeat (CRIS...

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Detalles Bibliográficos
Autores principales: Xu, Xingxing, Tao, Yonghui, Gao, Xiaobo, Zhang, Lei, Li, Xufang, Zou, Weiguo, Ruan, Kangcheng, Wang, Feng, Xu, Guo-liang, Hu, Ronggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853773/
https://www.ncbi.nlm.nih.gov/pubmed/27462456
http://dx.doi.org/10.1038/celldisc.2016.9

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