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Early life stress affects limited regional brain activity in depression

Early life stress (ELS) can alter brain function and increases the risk of major depressive disorder (MDD) in later life. This study investigated whether ELS contributes to differences in regional brain activity between MDD patients and healthy controls (HC), as measured by amplitude of low-frequenc...

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Autores principales: Du, Lian, Wang, Jingjie, Meng, Ben, Yong, Na, Yang, Xiangying, Huang, Qingling, Zhang, Yan, Yang, Lingling, Qu, Yuan, Chen, Zhu, Li, Yongmei, Lv, Fajin, Hu, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853783/
https://www.ncbi.nlm.nih.gov/pubmed/27138376
http://dx.doi.org/10.1038/srep25338
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author Du, Lian
Wang, Jingjie
Meng, Ben
Yong, Na
Yang, Xiangying
Huang, Qingling
Zhang, Yan
Yang, Lingling
Qu, Yuan
Chen, Zhu
Li, Yongmei
Lv, Fajin
Hu, Hua
author_facet Du, Lian
Wang, Jingjie
Meng, Ben
Yong, Na
Yang, Xiangying
Huang, Qingling
Zhang, Yan
Yang, Lingling
Qu, Yuan
Chen, Zhu
Li, Yongmei
Lv, Fajin
Hu, Hua
author_sort Du, Lian
collection PubMed
description Early life stress (ELS) can alter brain function and increases the risk of major depressive disorder (MDD) in later life. This study investigated whether ELS contributes to differences in regional brain activity between MDD patients and healthy controls (HC), as measured by amplitude of low-frequency fluctuation (ALFF)/fractional (f)ALFF. Eighteen first-episode, treatment-naïve MDD patients and HC were assessed with the Childhood Trauma Questionnaire and resting-state functional magnetic resonance imaging. We compared ALFF/fALFF between MDD patients and HC, with or without controlling for ELS, and determined whether ELS level was correlated with regional brain activity in each group. After regressing out ELS, we found that ALFF increased in bilateral amygdala and left orbital/cerebellum, while fALFF decreased in left inferior temporal and right middle frontal gyri in MDD patients relative to controls. ELS positively correlated with regional activity in the left cerebellum in MDD and in the right post-central/inferior temporal/superior frontal cingulate, inferior frontal gyrus and bilateral cerebellum in HC. Our findings indicate that there is only very limited region showing correlation between ELS and brain activity in MDD, while diverse areas in HC, suggesting ELS has few impacts on MDD patients.
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spelling pubmed-48537832016-05-16 Early life stress affects limited regional brain activity in depression Du, Lian Wang, Jingjie Meng, Ben Yong, Na Yang, Xiangying Huang, Qingling Zhang, Yan Yang, Lingling Qu, Yuan Chen, Zhu Li, Yongmei Lv, Fajin Hu, Hua Sci Rep Article Early life stress (ELS) can alter brain function and increases the risk of major depressive disorder (MDD) in later life. This study investigated whether ELS contributes to differences in regional brain activity between MDD patients and healthy controls (HC), as measured by amplitude of low-frequency fluctuation (ALFF)/fractional (f)ALFF. Eighteen first-episode, treatment-naïve MDD patients and HC were assessed with the Childhood Trauma Questionnaire and resting-state functional magnetic resonance imaging. We compared ALFF/fALFF between MDD patients and HC, with or without controlling for ELS, and determined whether ELS level was correlated with regional brain activity in each group. After regressing out ELS, we found that ALFF increased in bilateral amygdala and left orbital/cerebellum, while fALFF decreased in left inferior temporal and right middle frontal gyri in MDD patients relative to controls. ELS positively correlated with regional activity in the left cerebellum in MDD and in the right post-central/inferior temporal/superior frontal cingulate, inferior frontal gyrus and bilateral cerebellum in HC. Our findings indicate that there is only very limited region showing correlation between ELS and brain activity in MDD, while diverse areas in HC, suggesting ELS has few impacts on MDD patients. Nature Publishing Group 2016-05-03 /pmc/articles/PMC4853783/ /pubmed/27138376 http://dx.doi.org/10.1038/srep25338 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Du, Lian
Wang, Jingjie
Meng, Ben
Yong, Na
Yang, Xiangying
Huang, Qingling
Zhang, Yan
Yang, Lingling
Qu, Yuan
Chen, Zhu
Li, Yongmei
Lv, Fajin
Hu, Hua
Early life stress affects limited regional brain activity in depression
title Early life stress affects limited regional brain activity in depression
title_full Early life stress affects limited regional brain activity in depression
title_fullStr Early life stress affects limited regional brain activity in depression
title_full_unstemmed Early life stress affects limited regional brain activity in depression
title_short Early life stress affects limited regional brain activity in depression
title_sort early life stress affects limited regional brain activity in depression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853783/
https://www.ncbi.nlm.nih.gov/pubmed/27138376
http://dx.doi.org/10.1038/srep25338
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