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Relevance of HCN2-expressing human mesenchymal stem cells for the generation of biological pacemakers

BACKGROUND: The transfection of human mesenchymal stem cells (hMSCs) with the hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) gene has been demonstrated to provide biological pacing in dogs with complete heart block. The mechanism appears to be the generation of the ion curr...

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Detalles Bibliográficos
Autores principales:	Bruzauskaite, Ieva, Bironaite, Daiva, Bagdonas, Edvardas, Skeberdis, Vytenis Arvydas, Denkovskij, Jaroslav, Tamulevicius, Tomas, Uvarovas, Valentinas, Bernotiene, Eiva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853868/ https://www.ncbi.nlm.nih.gov/pubmed/27137910 http://dx.doi.org/10.1186/s13287-016-0326-z

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