The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals

NOD-like receptor (NLR) proteins are intracellular innate immune sensors/receptors that regulate immunity. This work shows that NLRX1 serves as a tumor suppressor in colitis-associated cancer (CAC) and sporadic colon cancer by keeping key tumor promoting pathways in check. Nlrx1(−/−) mice were highl...

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Detalles Bibliográficos
Autores principales: Koblansky, A. Alicia, Truax, Agnieszka D., Liu, Rongrong, Montgomery, Stephanie A., Ding, Shengli, Wilson, Justin E., Brickey, W. June, Mühlbauer, Marcus, McFadden, Rita-Marie T., Hu, Peizhen, Li, Zengshan, Jobin, Christian, Lund, Pauline Kay, Ting, Jenny P.-Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853907/
https://www.ncbi.nlm.nih.gov/pubmed/26971998
http://dx.doi.org/10.1016/j.celrep.2016.02.064

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