Reduced miR-659-3p Levels Correlate with Progranulin Increase in Hypoxic Conditions: Implications for Frontotemporal Dementia

Progranulin (PGRN) is a secreted protein expressed ubiquitously throughout the body, including the brain, where it localizes in neurons and is activated microglia. Loss-of-function mutations in the GRN gene are an important cause of familial frontotemporal lobar degeneration (FTLD). PGRN has a neuro...

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Detalles Bibliográficos
Autores principales: Piscopo, Paola, Grasso, Margherita, Fontana, Francesca, Crestini, Alessio, Puopolo, Maria, Del Vescovo, Valerio, Venerosi, Aldina, Calamandrei, Gemma, Vencken, Sebastian F., Greene, Catherine M., Confaloni, Annamaria, Denti, Michela A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853935/
https://www.ncbi.nlm.nih.gov/pubmed/27199656
http://dx.doi.org/10.3389/fnmol.2016.00031

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