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Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne

BACKGROUND: Acne vulgaris is the most common skin disease. Local and systemic antimicrobial drugs are used for its treatment. But increasing resistance of Propionibacterium acnes to antibiotics has been reported. MATERIALS AND METHODS: In a double-blind clinical trial, 40 patients with mild to moder...

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Autores principales: Mokhtari, Fatemeh, Faghihi, Gita, Basiri, Akram, Farhadi, Sadaf, Nilforoushzadeh, Mohammadali, Behfar, Shadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854036/
https://www.ncbi.nlm.nih.gov/pubmed/27169103
http://dx.doi.org/10.4103/2277-9175.180641
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author Mokhtari, Fatemeh
Faghihi, Gita
Basiri, Akram
Farhadi, Sadaf
Nilforoushzadeh, Mohammadali
Behfar, Shadi
author_facet Mokhtari, Fatemeh
Faghihi, Gita
Basiri, Akram
Farhadi, Sadaf
Nilforoushzadeh, Mohammadali
Behfar, Shadi
author_sort Mokhtari, Fatemeh
collection PubMed
description BACKGROUND: Acne vulgaris is the most common skin disease. Local and systemic antimicrobial drugs are used for its treatment. But increasing resistance of Propionibacterium acnes to antibiotics has been reported. MATERIALS AND METHODS: In a double-blind clinical trial, 40 patients with mild to moderate acne vulgaris were recruited. one side of the face was treated with Clindamycin Gel 1% and the other side with Azithromycin Topical Gel 2% BID for 8 weeks and then they were assessed. RESULTS: Average age was 21. 8 ± 7 years. 82.5% of them were female. Average number of papules, pustules and comedones was similarly reduced in both groups and, no significant difference was observed between the two groups (P > 0.05, repeated measurs ANOVA). The mean indexes of ASI and TLC also significantly decreased during treatment in both groups, no significant difference was observed between the two groups. (P > 0.05, repeated measurs ANOVA). Also, impact of both drugs on papules and pustules was 2-3 times greater than the effect on comedones. Average satisfaction score was not significant between the two groups (P = 0.6, repeated measurs ANOVA). finally, frequency distribution of complications was not significant between the two groups (P > 0.05, Fisher Exact test). CONCLUSION: Azithromycin gel has medical impact at least similar to Clindamycin Gel in treatment of mild to moderate acne vulgaris, and it may be consider as suitable drug for resistant acne to conventional topical therapy.
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spelling pubmed-48540362016-05-10 Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne Mokhtari, Fatemeh Faghihi, Gita Basiri, Akram Farhadi, Sadaf Nilforoushzadeh, Mohammadali Behfar, Shadi Adv Biomed Res Original Article BACKGROUND: Acne vulgaris is the most common skin disease. Local and systemic antimicrobial drugs are used for its treatment. But increasing resistance of Propionibacterium acnes to antibiotics has been reported. MATERIALS AND METHODS: In a double-blind clinical trial, 40 patients with mild to moderate acne vulgaris were recruited. one side of the face was treated with Clindamycin Gel 1% and the other side with Azithromycin Topical Gel 2% BID for 8 weeks and then they were assessed. RESULTS: Average age was 21. 8 ± 7 years. 82.5% of them were female. Average number of papules, pustules and comedones was similarly reduced in both groups and, no significant difference was observed between the two groups (P > 0.05, repeated measurs ANOVA). The mean indexes of ASI and TLC also significantly decreased during treatment in both groups, no significant difference was observed between the two groups. (P > 0.05, repeated measurs ANOVA). Also, impact of both drugs on papules and pustules was 2-3 times greater than the effect on comedones. Average satisfaction score was not significant between the two groups (P = 0.6, repeated measurs ANOVA). finally, frequency distribution of complications was not significant between the two groups (P > 0.05, Fisher Exact test). CONCLUSION: Azithromycin gel has medical impact at least similar to Clindamycin Gel in treatment of mild to moderate acne vulgaris, and it may be consider as suitable drug for resistant acne to conventional topical therapy. Medknow Publications & Media Pvt Ltd 2016-04-19 /pmc/articles/PMC4854036/ /pubmed/27169103 http://dx.doi.org/10.4103/2277-9175.180641 Text en Copyright: © 2016 Advanced Biomedical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Mokhtari, Fatemeh
Faghihi, Gita
Basiri, Akram
Farhadi, Sadaf
Nilforoushzadeh, Mohammadali
Behfar, Shadi
Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne
title Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne
title_full Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne
title_fullStr Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne
title_full_unstemmed Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne
title_short Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne
title_sort comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854036/
https://www.ncbi.nlm.nih.gov/pubmed/27169103
http://dx.doi.org/10.4103/2277-9175.180641
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