Cargando…

Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital

BACKGROUND: In April 2014, a surge in cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection was seen in Jeddah, Saudi Arabia. The aim of this study is to describe the demographic and clinical features, laboratory and radiological findings of MERS-CoV patients identified during t...

Descripción completa

Detalles Bibliográficos
Autores principales: Alraddadi, Basem, Bawareth, Noha, Omar, Haneen, Alsalmi, Hanadi, Alshukairi, Abeer, Qushmaq, Ismael, Feteih, Maun, Qutob, Mohammed, Wali, Ghassan, Khalid, Imran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854059/
https://www.ncbi.nlm.nih.gov/pubmed/27168861
http://dx.doi.org/10.4103/1817-1737.180027
_version_ 1782430173768974336
author Alraddadi, Basem
Bawareth, Noha
Omar, Haneen
Alsalmi, Hanadi
Alshukairi, Abeer
Qushmaq, Ismael
Feteih, Maun
Qutob, Mohammed
Wali, Ghassan
Khalid, Imran
author_facet Alraddadi, Basem
Bawareth, Noha
Omar, Haneen
Alsalmi, Hanadi
Alshukairi, Abeer
Qushmaq, Ismael
Feteih, Maun
Qutob, Mohammed
Wali, Ghassan
Khalid, Imran
author_sort Alraddadi, Basem
collection PubMed
description BACKGROUND: In April 2014, a surge in cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection was seen in Jeddah, Saudi Arabia. The aim of this study is to describe the demographic and clinical features, laboratory and radiological findings of MERS-CoV patients identified during this outbreak in a single tertiary hospital. METHODS: All laboratory-confirmed MERS-CoV cases who presented to King Faisal Specialist Hospital from March 1, 2014, to May 30, 2014, were identified. Patients' charts were reviewed for demographic information, comorbidities, clinical presentations, and outcomes. RESULTS: A total of 39 patients with confirmed MERS-CoV infection were identified. Twenty-one were male (54%), aged 40 ± 19 years and included 3 (8%) pediatric patients (<18-year-old). 16 (41%) patients were health care workers. Twenty-one (53%) patients were previously healthy whereas eighteen (47%) had at least one comorbidity. The predominant comorbidities included hypertension (31%), diabetes (26%), respiratory (23%), and renal disease (18%). Thirty patients (81%) were symptomatic at presentation, fever (69%) being the most common complaint. The overall mortality rate was 28%. In univariate analysis, older age, hypertension, and chronic kidney disease were associated with mortality. CONCLUSIONS: MERS-CoV presentation varies from asymptomatic infection to severe respiratory disease causing death. Future studies to identify the risk factors for worse outcome are needed.
format Online
Article
Text
id pubmed-4854059
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-48540592016-05-10 Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital Alraddadi, Basem Bawareth, Noha Omar, Haneen Alsalmi, Hanadi Alshukairi, Abeer Qushmaq, Ismael Feteih, Maun Qutob, Mohammed Wali, Ghassan Khalid, Imran Ann Thorac Med Original Article BACKGROUND: In April 2014, a surge in cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection was seen in Jeddah, Saudi Arabia. The aim of this study is to describe the demographic and clinical features, laboratory and radiological findings of MERS-CoV patients identified during this outbreak in a single tertiary hospital. METHODS: All laboratory-confirmed MERS-CoV cases who presented to King Faisal Specialist Hospital from March 1, 2014, to May 30, 2014, were identified. Patients' charts were reviewed for demographic information, comorbidities, clinical presentations, and outcomes. RESULTS: A total of 39 patients with confirmed MERS-CoV infection were identified. Twenty-one were male (54%), aged 40 ± 19 years and included 3 (8%) pediatric patients (<18-year-old). 16 (41%) patients were health care workers. Twenty-one (53%) patients were previously healthy whereas eighteen (47%) had at least one comorbidity. The predominant comorbidities included hypertension (31%), diabetes (26%), respiratory (23%), and renal disease (18%). Thirty patients (81%) were symptomatic at presentation, fever (69%) being the most common complaint. The overall mortality rate was 28%. In univariate analysis, older age, hypertension, and chronic kidney disease were associated with mortality. CONCLUSIONS: MERS-CoV presentation varies from asymptomatic infection to severe respiratory disease causing death. Future studies to identify the risk factors for worse outcome are needed. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4854059/ /pubmed/27168861 http://dx.doi.org/10.4103/1817-1737.180027 Text en Copyright: © 2016 Annals of Thoracic Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Alraddadi, Basem
Bawareth, Noha
Omar, Haneen
Alsalmi, Hanadi
Alshukairi, Abeer
Qushmaq, Ismael
Feteih, Maun
Qutob, Mohammed
Wali, Ghassan
Khalid, Imran
Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital
title Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital
title_full Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital
title_fullStr Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital
title_full_unstemmed Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital
title_short Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital
title_sort patient characteristics infected with middle east respiratory syndrome coronavirus infection in a tertiary hospital
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854059/
https://www.ncbi.nlm.nih.gov/pubmed/27168861
http://dx.doi.org/10.4103/1817-1737.180027
work_keys_str_mv AT alraddadibasem patientcharacteristicsinfectedwithmiddleeastrespiratorysyndromecoronavirusinfectioninatertiaryhospital
AT bawarethnoha patientcharacteristicsinfectedwithmiddleeastrespiratorysyndromecoronavirusinfectioninatertiaryhospital
AT omarhaneen patientcharacteristicsinfectedwithmiddleeastrespiratorysyndromecoronavirusinfectioninatertiaryhospital
AT alsalmihanadi patientcharacteristicsinfectedwithmiddleeastrespiratorysyndromecoronavirusinfectioninatertiaryhospital
AT alshukairiabeer patientcharacteristicsinfectedwithmiddleeastrespiratorysyndromecoronavirusinfectioninatertiaryhospital
AT qushmaqismael patientcharacteristicsinfectedwithmiddleeastrespiratorysyndromecoronavirusinfectioninatertiaryhospital
AT feteihmaun patientcharacteristicsinfectedwithmiddleeastrespiratorysyndromecoronavirusinfectioninatertiaryhospital
AT qutobmohammed patientcharacteristicsinfectedwithmiddleeastrespiratorysyndromecoronavirusinfectioninatertiaryhospital
AT walighassan patientcharacteristicsinfectedwithmiddleeastrespiratorysyndromecoronavirusinfectioninatertiaryhospital
AT khalidimran patientcharacteristicsinfectedwithmiddleeastrespiratorysyndromecoronavirusinfectioninatertiaryhospital