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Histone H2AX phosphorylation as a measure of DNA double-strand breaks and a marker of environmental stress and disease activity in lupus

OBJECTIVE: Defective or inefficient DNA double-strand break (DSB) repair results in failure to preserve genomic integrity leading to apoptotic cell death, a hallmark of systemic lupus erythematosus (SLE). Compelling evidence linked environmental factors that increase oxidative stress with SLE risk a...

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Detalles Bibliográficos
Autores principales:	Namas, Rajaie, Renauer, Paul, Ognenovski, Mikhail, Tsou, Pei-Suen, Sawalha, Amr H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2016
Materias:	Biomarker Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854117/ https://www.ncbi.nlm.nih.gov/pubmed/27158526 http://dx.doi.org/10.1136/lupus-2016-000148

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