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A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy: A multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking

PURPOSE: A study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery systems and institutions, the dosimetric accuracy is improved with adaptive treatments over non-adaptive radiotherapy in the presence of patient-measured tumor motion. METHODS AND M...

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Detalles Bibliográficos
Autores principales: Colvill, Emma, Booth, Jeremy, Nill, Simeon, Fast, Martin, Bedford, James, Oelfke, Uwe, Nakamura, Mitsuhiro, Poulsen, Per, Worm, Esben, Hansen, Rune, Ravkilde, Thomas, Scherman Rydhög, Jonas, Pommer, Tobias, Munck af Rosenschold, Per, Lang, Stephanie, Guckenberger, Matthias, Groh, Christian, Herrmann, Christian, Verellen, Dirk, Poels, Kenneth, Wang, Lei, Hadsell, Michael, Sothmann, Thilo, Blanck, Oliver, Keall, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Scientific Publishers 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854175/
https://www.ncbi.nlm.nih.gov/pubmed/27016171
http://dx.doi.org/10.1016/j.radonc.2016.03.006
Descripción
Sumario:PURPOSE: A study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery systems and institutions, the dosimetric accuracy is improved with adaptive treatments over non-adaptive radiotherapy in the presence of patient-measured tumor motion. METHODS AND MATERIALS: Ten institutions with robotic(2), gimbaled(2), MLC(4) or couch tracking(2) used common materials including CT and structure sets, motion traces and planning protocols to create a lung and a prostate plan. For each motion trace, the plan was delivered twice to a moving dosimeter; with and without real-time adaptation. Each measurement was compared to a static measurement and the percentage of failed points for γ-tests recorded. RESULTS: For all lung traces all measurement sets show improved dose accuracy with a mean 2%/2 mm γ-fail rate of 1.6% with adaptation and 15.2% without adaptation (p < 0.001). For all prostate the mean 2%/2 mm γ-fail rate was 1.4% with adaptation and 17.3% without adaptation (p < 0.001). The difference between the four systems was small with an average 2%/2 mm γ-fail rate of <3% for all systems with adaptation for lung and prostate. CONCLUSIONS: The investigated systems all accounted for realistic tumor motion accurately and performed to a similar high standard, with real-time adaptation significantly outperforming non-adaptive delivery methods.