Photoredox Cross-Coupling: Ir/Ni Dual Catalysis for the Synthesis of Benzylic Ethers

[Image: see text] Single-electron transmetalation has emerged as an enabling paradigm for the cross-coupling of C(sp(3)) hybridized organotrifluoroborates. Cross-coupling of α-alkoxymethyltrifluoroborates with aryl and heteroaryl bromides has been demonstrated by employing dual catalysis with a comb...

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Autores principales: Karakaya, Idris, Primer, David N., Molander, Gary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854197/
https://www.ncbi.nlm.nih.gov/pubmed/26079182
http://dx.doi.org/10.1021/acs.orglett.5b01463
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author Karakaya, Idris
Primer, David N.
Molander, Gary A.
author_facet Karakaya, Idris
Primer, David N.
Molander, Gary A.
author_sort Karakaya, Idris
collection PubMed
description [Image: see text] Single-electron transmetalation has emerged as an enabling paradigm for the cross-coupling of C(sp(3)) hybridized organotrifluoroborates. Cross-coupling of α-alkoxymethyltrifluoroborates with aryl and heteroaryl bromides has been demonstrated by employing dual catalysis with a combination of an iridium photoredox catalyst and a Ni cross-coupling catalyst. The resulting method enables the alkoxymethylation of diverse (hetero)arenes under mild, room-temperature conditions.
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spelling pubmed-48541972016-06-16 Photoredox Cross-Coupling: Ir/Ni Dual Catalysis for the Synthesis of Benzylic Ethers Karakaya, Idris Primer, David N. Molander, Gary A. Org Lett [Image: see text] Single-electron transmetalation has emerged as an enabling paradigm for the cross-coupling of C(sp(3)) hybridized organotrifluoroborates. Cross-coupling of α-alkoxymethyltrifluoroborates with aryl and heteroaryl bromides has been demonstrated by employing dual catalysis with a combination of an iridium photoredox catalyst and a Ni cross-coupling catalyst. The resulting method enables the alkoxymethylation of diverse (hetero)arenes under mild, room-temperature conditions. American Chemical Society 2015-06-16 2015-07-02 /pmc/articles/PMC4854197/ /pubmed/26079182 http://dx.doi.org/10.1021/acs.orglett.5b01463 Text en Copyright © 2015 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Karakaya, Idris
Primer, David N.
Molander, Gary A.
Photoredox Cross-Coupling: Ir/Ni Dual Catalysis for the Synthesis of Benzylic Ethers
title Photoredox Cross-Coupling: Ir/Ni Dual Catalysis for the Synthesis of Benzylic Ethers
title_full Photoredox Cross-Coupling: Ir/Ni Dual Catalysis for the Synthesis of Benzylic Ethers
title_fullStr Photoredox Cross-Coupling: Ir/Ni Dual Catalysis for the Synthesis of Benzylic Ethers
title_full_unstemmed Photoredox Cross-Coupling: Ir/Ni Dual Catalysis for the Synthesis of Benzylic Ethers
title_short Photoredox Cross-Coupling: Ir/Ni Dual Catalysis for the Synthesis of Benzylic Ethers
title_sort photoredox cross-coupling: ir/ni dual catalysis for the synthesis of benzylic ethers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854197/
https://www.ncbi.nlm.nih.gov/pubmed/26079182
http://dx.doi.org/10.1021/acs.orglett.5b01463
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AT primerdavidn photoredoxcrosscouplingirnidualcatalysisforthesynthesisofbenzylicethers
AT molandergarya photoredoxcrosscouplingirnidualcatalysisforthesynthesisofbenzylicethers

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