Cargando…
Genetic Contribution to the Development of Radiographic Knee Osteoarthritis in a Population Presenting with Nonacute Knee Symptoms a Decade Earlier
This study examined the contribution of the osteoarthritis (OA) susceptibility genes ASPN, GDF5, DIO2, and the 7q22 region to the development of radiographic knee OA in patients with a mean age of 40.6 ± 7.9 years (standard deviation) and who suffered from nonacute knee complaints a decade earlier....
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854216/ https://www.ncbi.nlm.nih.gov/pubmed/27158223 http://dx.doi.org/10.4137/CMAMD.S30657 |
_version_ | 1782430191903047680 |
---|---|
author | Huétink, Kasper van der Voort, Paul Bloem, Johan L. Nelissen, Rob G. H. H. Meulenbelt, Ingrid |
author_facet | Huétink, Kasper van der Voort, Paul Bloem, Johan L. Nelissen, Rob G. H. H. Meulenbelt, Ingrid |
author_sort | Huétink, Kasper |
collection | PubMed |
description | This study examined the contribution of the osteoarthritis (OA) susceptibility genes ASPN, GDF5, DIO2, and the 7q22 region to the development of radiographic knee OA in patients with a mean age of 40.6 ± 7.9 years (standard deviation) and who suffered from nonacute knee complaints a decade earlier. Dose–response associations of four single nucleotide polymorphisms(SNPs) in the susceptibility genes were determined by comparing 36 patients who showed the development of OA on radiographs (Kellgren and Lawrence score ≥1) with 88 patients having normal cartilage with no development of OA on radiographs. Multivariate logistic regression analysis including the variables such as age, gender, body mass index, and reported knee trauma was performed. A dose–response association of DIO2 SNP rs225014: odds ratio (OR) 2.3, 95% confidence interval (CI) 1.1–4.5 (P = 0.019) and GDF5 SNP rs143383: OR 2.0, 95% CI 1.1–3.8 (P = 0.031) was observed with knee OA development. The ASPN and 7q22 SNPs were not associated with OA development. |
format | Online Article Text |
id | pubmed-4854216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-48542162016-05-06 Genetic Contribution to the Development of Radiographic Knee Osteoarthritis in a Population Presenting with Nonacute Knee Symptoms a Decade Earlier Huétink, Kasper van der Voort, Paul Bloem, Johan L. Nelissen, Rob G. H. H. Meulenbelt, Ingrid Clin Med Insights Arthritis Musculoskelet Disord Original Research This study examined the contribution of the osteoarthritis (OA) susceptibility genes ASPN, GDF5, DIO2, and the 7q22 region to the development of radiographic knee OA in patients with a mean age of 40.6 ± 7.9 years (standard deviation) and who suffered from nonacute knee complaints a decade earlier. Dose–response associations of four single nucleotide polymorphisms(SNPs) in the susceptibility genes were determined by comparing 36 patients who showed the development of OA on radiographs (Kellgren and Lawrence score ≥1) with 88 patients having normal cartilage with no development of OA on radiographs. Multivariate logistic regression analysis including the variables such as age, gender, body mass index, and reported knee trauma was performed. A dose–response association of DIO2 SNP rs225014: odds ratio (OR) 2.3, 95% confidence interval (CI) 1.1–4.5 (P = 0.019) and GDF5 SNP rs143383: OR 2.0, 95% CI 1.1–3.8 (P = 0.031) was observed with knee OA development. The ASPN and 7q22 SNPs were not associated with OA development. Libertas Academica 2016-04-28 /pmc/articles/PMC4854216/ /pubmed/27158223 http://dx.doi.org/10.4137/CMAMD.S30657 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License. |
spellingShingle | Original Research Huétink, Kasper van der Voort, Paul Bloem, Johan L. Nelissen, Rob G. H. H. Meulenbelt, Ingrid Genetic Contribution to the Development of Radiographic Knee Osteoarthritis in a Population Presenting with Nonacute Knee Symptoms a Decade Earlier |
title | Genetic Contribution to the Development of Radiographic Knee Osteoarthritis in a Population Presenting with Nonacute Knee Symptoms a Decade Earlier |
title_full | Genetic Contribution to the Development of Radiographic Knee Osteoarthritis in a Population Presenting with Nonacute Knee Symptoms a Decade Earlier |
title_fullStr | Genetic Contribution to the Development of Radiographic Knee Osteoarthritis in a Population Presenting with Nonacute Knee Symptoms a Decade Earlier |
title_full_unstemmed | Genetic Contribution to the Development of Radiographic Knee Osteoarthritis in a Population Presenting with Nonacute Knee Symptoms a Decade Earlier |
title_short | Genetic Contribution to the Development of Radiographic Knee Osteoarthritis in a Population Presenting with Nonacute Knee Symptoms a Decade Earlier |
title_sort | genetic contribution to the development of radiographic knee osteoarthritis in a population presenting with nonacute knee symptoms a decade earlier |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854216/ https://www.ncbi.nlm.nih.gov/pubmed/27158223 http://dx.doi.org/10.4137/CMAMD.S30657 |
work_keys_str_mv | AT huetinkkasper geneticcontributiontothedevelopmentofradiographickneeosteoarthritisinapopulationpresentingwithnonacutekneesymptomsadecadeearlier AT vandervoortpaul geneticcontributiontothedevelopmentofradiographickneeosteoarthritisinapopulationpresentingwithnonacutekneesymptomsadecadeearlier AT bloemjohanl geneticcontributiontothedevelopmentofradiographickneeosteoarthritisinapopulationpresentingwithnonacutekneesymptomsadecadeearlier AT nelissenrobghh geneticcontributiontothedevelopmentofradiographickneeosteoarthritisinapopulationpresentingwithnonacutekneesymptomsadecadeearlier AT meulenbeltingrid geneticcontributiontothedevelopmentofradiographickneeosteoarthritisinapopulationpresentingwithnonacutekneesymptomsadecadeearlier |