Cargando…

Midazolam regulated caspase pathway, endoplasmic reticulum stress, autophagy, and cell cycle to induce apoptosis in MA-10 mouse Leydig tumor cells

PURPOSE: Midazolam is widely used as a sedative and anesthetic induction agent by modulating the different GABA receptors in the central nervous system. Studies have also shown that midazolam has an anticancer effect on various tumors. In a previous study, we found that midazolam could induce MA-10...

Descripción completa

Detalles Bibliográficos
Autores principales:	So, Edmund Cheung, Chen, Yung-Chia, Wang, Shu-Chun, Wu, Chia-Ching, Huang, Man-Chi, Lai, Meng-Shao, Pan, Bo-Syong, Kang, Fu-Chi, Huang, Bu-Miin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854247/ https://www.ncbi.nlm.nih.gov/pubmed/27175086 http://dx.doi.org/10.2147/OTT.S101671

Ejemplares similares

Midazolam activates caspase, MAPKs and endoplasmic reticulum stress pathways, and inhibits cell cycle and Akt pathway, to induce apoptosis in TM3 mouse Leydig progenitor cells
por: Kang, Fu-Chi, et al.
Publicado: (2018)

Midazolam induces apoptosis in MA-10 mouse Leydig tumor cells through caspase activation and the involvement of MAPK signaling pathway
por: So, Edmund Cheung, et al.
Publicado: (2014)

Apoptotic effect of cordycepin combined with cisplatin and/or paclitaxel on MA-10 mouse Leydig tumor cells
por: Kang, Fu-Chi, et al.
Publicado: (2015)

The Effect of Cordycepin on Steroidogenesis and Apoptosis in MA-10 Mouse Leydig Tumor Cells
por: Pan, Bo-Syong, et al.
Publicado: (2011)

Cordycepin Induced MA-10 Mouse Leydig Tumor Cell Apoptosis through Caspase-9 Pathway
por: Jen, Chun-Yi, et al.
Publicado: (2011)

Arsenic compounds activate MAPK and inhibit Akt pathways to induce apoptosis in MA‐10 mouse Leydig tumor cells
por: Juan, Wei‐Sheng, et al.
Publicado: (2022)

Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways
por: Pan, Bo-Syong, et al.
Publicado: (2015)

Midazolam inhibits chondrogenesis via peripheral benzodiazepine receptor in human mesenchymal stem cells
por: Chen, Yung‐Ching, et al.
Publicado: (2018)

Cordycepin inhibits ERK pathway to suppress FGF9-induced tumorigenesis with MA-10 mouse Leydig tumor cells
por: Chen, Li-Ching, et al.
Publicado: (2023)

Cordycepin enhances cisplatin apoptotic effect through caspase/MAPK pathways in human head and neck tumor cells
por: Chen, Ying-Hui, et al.
Publicado: (2013)

FGF9/FGFR2 increase cell proliferation by activating ERK1/2, Rb/E2F1, and cell cycle pathways in mouse Leydig tumor cells
por: Chang, Ming‐Min, et al.
Publicado: (2018)

Effects of Midazolam on the Development of Adult Leydig Cells From Stem Cells In Vitro
por: Zhao, Xingyi, et al.
Publicado: (2021)

Cordycepin‐induced unfolded protein response‐dependent cell death, and AKT/MAPK‐mediated drug resistance in mouse testicular tumor cells
por: Chang, Ming‐Min, et al.
Publicado: (2019)

HC diet inhibited testosterone synthesis by activating endoplasmic reticulum stress in testicular Leydig cells
por: Yu, Chunxiao, et al.
Publicado: (2019)

Midazolam’s Effects on Delayed-Rectifier K(+) Current and Intermediate-Conductance Ca(2+)-Activated K(+) Channel in Jurkat T-lymphocytes
por: Foo, Ning-Ping, et al.
Publicado: (2021)

Anticancer Effects of Midazolam on Lung and Breast Cancers by Inhibiting Cell Proliferation and Epithelial-Mesenchymal Transition
por: Lu, Hsin-Ling, et al.
Publicado: (2021)

Functional study of Cordyceps sinensis and cordycepin in male reproduction: A review
por: Chen, Yung-Chia, et al.
Publicado: (2016)

16-Hydroxycleroda-3,13-dien-15,16-olide induces anoikis in human renal cell carcinoma cells: involvement of focal adhesion disassembly and signaling
por: Chen, Yu-Chi, et al.
Publicado: (2018)

Induction of mitochondrial-dependent apoptosis by essential oil of Toona sinensis root through Akt, mTOR and NF-κB signalling pathways in human renal cell carcinoma cells
por: Chen, Yu-Chi, et al.
Publicado: (2021)

Inhibition of autophagy by 3-MA enhances endoplasmic reticulum stress-induced apoptosis in human nasopharyngeal carcinoma cells
por: SONG, LELE, et al.
Publicado: (2013)

Gigantol Improves Cholesterol Metabolism and Progesterone Biosynthesis in MA-10 Leydig Cells
por: Basque, Audrey, et al.
Publicado: (2021)

Curcumin protects against palmitic acid-induced apoptosis via the inhibition of endoplasmic reticulum stress in testicular Leydig cells
por: Chen, Zhi, et al.
Publicado: (2019)

Fibroblast Growth Factor 9 Activates Akt and MAPK Pathways to Stimulate Steroidogenesis in Mouse Leydig Cells
por: Lai, Meng-Shao, et al.
Publicado: (2014)

Caspase-mediated nuclear pore complex trimming in cell differentiation and endoplasmic reticulum stress
por: Cho, Ukrae H, et al.
Publicado: (2023)

Functional metabolite reserves and lipid homeostasis revealed by the MA-10 Leydig cell metabolome
por: Koganti, Prasanthi P, et al.
Publicado: (2022)

Endoplasmic reticulum stress-induced PCD and caspase-like activities involved
por: Cai, Yao-Min, et al.
Publicado: (2014)

Kaempferol mitigates Endoplasmic Reticulum Stress Induced Cell Death by targeting caspase 3/7
por: Abdullah, Ahmad, et al.
Publicado: (2018)

Mitochondrial TSPO Deficiency Triggers Retrograde Signaling in MA-10 Mouse Tumor Leydig Cells
por: Fan, Jinjiang, et al.
Publicado: (2020)

Cordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis
por: Wang, Chia-Yih, et al.
Publicado: (2020)

Polyphenol-Rich Extracts from Toona sinensis Bark and Fruit Ameliorate Free Fatty Acid-Induced Lipogenesis through AMPK and LC3 Pathways
por: Chen, Yung-Chia, et al.
Publicado: (2019)

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death
por: Hitomi, Junichi, et al.
Publicado: (2004)

Uncovering a Dual Regulatory Role for Caspases During Endoplasmic Reticulum Stress-induced Cell Death
por: Anania, Veronica G., et al.
Publicado: (2016)

Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress
por: Shemorry, Anna, et al.
Publicado: (2019)

Caspase-8 Regulates Endoplasmic Reticulum Stress-Induced Necroptosis Independent of the Apoptosis Pathway in Auditory Cells
por: Kishino, Akihiro, et al.
Publicado: (2019)

Bufalin Induces Apoptosis of Human Osteosarcoma U-2 OS Cells through Endoplasmic Reticulum Stress, Caspase- and Mitochondria-Dependent Signaling Pathways
por: Lee, Ching-Hsiao, et al.
Publicado: (2017)

Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities
por: Chen, Yung-Chia, et al.
Publicado: (2021)

16-Hydroxycleroda-3,13-Dien-15,16-Olide Induces Apoptosis in Human Bladder Cancer Cells through Cell Cycle Arrest, Mitochondria ROS Overproduction, and Inactivation of EGFR-Related Signalling Pathways
por: Chen, Yu-Chi, et al.
Publicado: (2020)

Fatty acids suppress the steroidogenesis of the MA-10 mouse Leydig cell line by downregulating CYP11A1 and inhibiting late-stage autophagy
por: Huang, Chien, et al.
Publicado: (2021)

Endoplasmic Reticulum Stress Mediates Radiation-Induced Autophagy via PERK-eIF2α in Caspase-3/7 Deficient Cells
por: Kim, Kwang Woon, et al.
Publicado: (2010)

Involvement of Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in Advanced Glycation End Products-Induced Glomerular Mesangial Cell Injury
por: Chiang, Chih-Kang, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_cks47m0vut1biv6ifj3q4c8k9f