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Association between levels of vitamin D and inflammatory markers in healthy women
BACKGROUND: No one can deny that the biological importance of vitamin D is much beyond its classical role in bone metabolism. Several recent publications have highlighted its potential role in the functioning of the immune system. The overall objective of this study was to look into possible correla...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854309/ https://www.ncbi.nlm.nih.gov/pubmed/27175089 http://dx.doi.org/10.2147/JIR.S103298 |
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author | Azizieh, Fawaz Alyahya, Khulood O Raghupathy, Raj |
author_facet | Azizieh, Fawaz Alyahya, Khulood O Raghupathy, Raj |
author_sort | Azizieh, Fawaz |
collection | PubMed |
description | BACKGROUND: No one can deny that the biological importance of vitamin D is much beyond its classical role in bone metabolism. Several recent publications have highlighted its potential role in the functioning of the immune system. The overall objective of this study was to look into possible correlations between levels of vitamin D and inflammatory markers in sera of healthy adult women. These markers included proinflammatory cytokines (interleukin [IL]-1β, IL-6, IL-8, IL-17, interferon [IFN]-γ, and tumor necrosis factor [TNF]-α), anti-inflammatory cytokines (IL-4, IL-10, and IL-13), as well as C-reactive protein (CRP) as a general indicator of inflammation. METHODS: Venous blood samples were collected from 118 healthy adult women and serum levels of vitamin D, CRP, proinflammatory cytokines (IL-1β, IL-6, IL-8, IL-17, IFN-γ, and TNF-α), and anti-inflammatory cytokines (IL-4, IL-10, and IL-13) were measured. RESULTS: There were no significant direct correlations between serum levels of vitamin D and any of the inflammatory markers measured. However, subjects with deficient levels of vitamin D and high CRP produced significantly higher levels of the proinflammatory cytokines (TNF-α and IL-8) as compared to subjects with low CRP levels with nondeficient and deficient levels of vitamin D. Further, the anti-inflammatory/proinflammatory ratios suggest a role of vitamin D in maintaining an anti-inflammatory environment at low levels of CRP, an association that is weaker at high CRP levels in subjects with subclinical inflammatory situations. CONCLUSION: These data point to a possible role of vitamin D as a contributing factor in balancing cytokines toward an anti-inflammatory role in inflammatory situations. |
format | Online Article Text |
id | pubmed-4854309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48543092016-05-12 Association between levels of vitamin D and inflammatory markers in healthy women Azizieh, Fawaz Alyahya, Khulood O Raghupathy, Raj J Inflamm Res Original Research BACKGROUND: No one can deny that the biological importance of vitamin D is much beyond its classical role in bone metabolism. Several recent publications have highlighted its potential role in the functioning of the immune system. The overall objective of this study was to look into possible correlations between levels of vitamin D and inflammatory markers in sera of healthy adult women. These markers included proinflammatory cytokines (interleukin [IL]-1β, IL-6, IL-8, IL-17, interferon [IFN]-γ, and tumor necrosis factor [TNF]-α), anti-inflammatory cytokines (IL-4, IL-10, and IL-13), as well as C-reactive protein (CRP) as a general indicator of inflammation. METHODS: Venous blood samples were collected from 118 healthy adult women and serum levels of vitamin D, CRP, proinflammatory cytokines (IL-1β, IL-6, IL-8, IL-17, IFN-γ, and TNF-α), and anti-inflammatory cytokines (IL-4, IL-10, and IL-13) were measured. RESULTS: There were no significant direct correlations between serum levels of vitamin D and any of the inflammatory markers measured. However, subjects with deficient levels of vitamin D and high CRP produced significantly higher levels of the proinflammatory cytokines (TNF-α and IL-8) as compared to subjects with low CRP levels with nondeficient and deficient levels of vitamin D. Further, the anti-inflammatory/proinflammatory ratios suggest a role of vitamin D in maintaining an anti-inflammatory environment at low levels of CRP, an association that is weaker at high CRP levels in subjects with subclinical inflammatory situations. CONCLUSION: These data point to a possible role of vitamin D as a contributing factor in balancing cytokines toward an anti-inflammatory role in inflammatory situations. Dove Medical Press 2016-04-27 /pmc/articles/PMC4854309/ /pubmed/27175089 http://dx.doi.org/10.2147/JIR.S103298 Text en © 2016 Azizieh et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Azizieh, Fawaz Alyahya, Khulood O Raghupathy, Raj Association between levels of vitamin D and inflammatory markers in healthy women |
title | Association between levels of vitamin D and inflammatory markers in healthy women |
title_full | Association between levels of vitamin D and inflammatory markers in healthy women |
title_fullStr | Association between levels of vitamin D and inflammatory markers in healthy women |
title_full_unstemmed | Association between levels of vitamin D and inflammatory markers in healthy women |
title_short | Association between levels of vitamin D and inflammatory markers in healthy women |
title_sort | association between levels of vitamin d and inflammatory markers in healthy women |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854309/ https://www.ncbi.nlm.nih.gov/pubmed/27175089 http://dx.doi.org/10.2147/JIR.S103298 |
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