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Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes

Skatole (3-methylindole) is a product of bacterial fermentation of tryptophan in the intestine. A significant amount of skatole can also be inhaled during cigarette smoking. Skatole is a pulmonary toxin that induces the expression of aryl hydrocarbon receptor (AhR) regulated genes, such as cytochrom...

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Detalles Bibliográficos
Autores principales:	Rasmussen, Martin Krøyer, Balaguer, Patrick, Ekstrand, Bo, Daujat-Chavanieu, Martine, Gerbal-Chaloin, Sabine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854444/ https://www.ncbi.nlm.nih.gov/pubmed/27138278 http://dx.doi.org/10.1371/journal.pone.0154629

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