Novel extrapancreatic effects of incretin

The hormonal factors implicated as transmitters of signals from the gut to pancreatic β‐cells are referred to as incretins. Gastric inhibitory polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are incretins. In addition to the insulinotropic effects, we have shown, using the GIP receptor and GLP...

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Detalles Bibliográficos
Autores principales: Yamada, Yuichiro, Tsukiyama, Katsushi, Sato, Takehiro, Shimizu, Tatsunori, Fujita, Hiroki, Narita, Takuma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Proceedings of INCRETIN 2015, A Symposium Celebrating the 45th Anniversary of the Discovery of GIP, 29–31 July 2015, Vancouver, Canada. This publication has been supported by: The Local Organizing Committee of INCRETIN 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854509/
https://www.ncbi.nlm.nih.gov/pubmed/27186360
http://dx.doi.org/10.1111/jdi.12495
Descripción
Sumario:The hormonal factors implicated as transmitters of signals from the gut to pancreatic β‐cells are referred to as incretins. Gastric inhibitory polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are incretins. In addition to the insulinotropic effects, we have shown, using the GIP receptor and GLP‐1 receptor‐deficient mice, that GIP and GLP‐1 have direct actions on adipocytes and the kidney, respectively. Because GIP receptors and GLP‐1 receptors are differentially expressed in a tissue‐specific manner, GIP and GLP‐1 have specific physiological activities, and further comprehensive characterization of the extrapancreatic actions of GIP and GLP‐1 is anticipated, as dipeptidyl peptidase IV inhibitors activate both GIP and GLP‐1 signaling.

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