Cargando…
Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance
Mutations in the P53 pathway are a hallmark of human cancer. The identification of pathways upon which p53-deficient cells depend could reveal therapeutic targets that may spare normal cells with intact p53. In contrast to P53 point mutations in other cancer, complete loss of P53 is a frequent event...
Autores principales: | Walia, Mannu K, Ho, Patricia MW, Taylor, Scott, Ng, Alvin JM, Gupte, Ankita, Chalk, Alistair M, Zannettino, Andrew CW, Martin, T John, Walkley, Carl R |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854515/ https://www.ncbi.nlm.nih.gov/pubmed/27070462 http://dx.doi.org/10.7554/eLife.13446 |
Ejemplares similares
-
PTHrP, its receptor, and protein kinase A activation in osteosarcoma
por: Walkley, Carl R, et al.
Publicado: (2014) -
PTHrP and the PTH/PTHrP receptor are co-expressed in human breast and colon tumours.
por: Carron, J. A., et al.
Publicado: (1997) -
Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53
por: Walia, Mannu K., et al.
Publicado: (2018) -
BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells
por: Baker, Emma K, et al.
Publicado: (2015) -
Exogenous PTHrP Repairs the Damaged Fracture Healing of PTHrP+/− Mice and Accelerates Fracture Healing of Wild Mice
por: Wang, Yinhe, et al.
Publicado: (2017)