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An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans

As a common neurotransmitter in the nervous system, γ-aminobutyric acid (GABA) modulates locomotory patterns in both vertebrates and invertebrates. However, the signaling mechanisms underlying the behavioral effects of GABAergic modulation are not completely understood. Here, we demonstrate that a G...

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Autores principales: Shen, Yu, Wen, Quan, Liu, He, Zhong, Connie, Qin, Yuqi, Harris, Gareth, Kawano, Taizo, Wu, Min, Xu, Tianqi, Samuel, Aravinthan DT, Zhang, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854516/
https://www.ncbi.nlm.nih.gov/pubmed/27138642
http://dx.doi.org/10.7554/eLife.14197
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author Shen, Yu
Wen, Quan
Liu, He
Zhong, Connie
Qin, Yuqi
Harris, Gareth
Kawano, Taizo
Wu, Min
Xu, Tianqi
Samuel, Aravinthan DT
Zhang, Yun
author_facet Shen, Yu
Wen, Quan
Liu, He
Zhong, Connie
Qin, Yuqi
Harris, Gareth
Kawano, Taizo
Wu, Min
Xu, Tianqi
Samuel, Aravinthan DT
Zhang, Yun
author_sort Shen, Yu
collection PubMed
description As a common neurotransmitter in the nervous system, γ-aminobutyric acid (GABA) modulates locomotory patterns in both vertebrates and invertebrates. However, the signaling mechanisms underlying the behavioral effects of GABAergic modulation are not completely understood. Here, we demonstrate that a GABAergic signal in C. elegans modulates the amplitude of undulatory head bending through extrasynaptic neurotransmission and conserved metabotropic receptors. We show that the GABAergic RME head motor neurons generate undulatory activity patterns that correlate with head bending and the activity of RME causally links with head bending amplitude. The undulatory activity of RME is regulated by a pair of cholinergic head motor neurons SMD, which facilitate head bending, and inhibits SMD to limit head bending. The extrasynaptic neurotransmission between SMD and RME provides a gain control system to set head bending amplitude to a value correlated with optimal efficiency of forward movement. DOI: http://dx.doi.org/10.7554/eLife.14197.001
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spelling pubmed-48545162016-05-05 An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans Shen, Yu Wen, Quan Liu, He Zhong, Connie Qin, Yuqi Harris, Gareth Kawano, Taizo Wu, Min Xu, Tianqi Samuel, Aravinthan DT Zhang, Yun eLife Neuroscience As a common neurotransmitter in the nervous system, γ-aminobutyric acid (GABA) modulates locomotory patterns in both vertebrates and invertebrates. However, the signaling mechanisms underlying the behavioral effects of GABAergic modulation are not completely understood. Here, we demonstrate that a GABAergic signal in C. elegans modulates the amplitude of undulatory head bending through extrasynaptic neurotransmission and conserved metabotropic receptors. We show that the GABAergic RME head motor neurons generate undulatory activity patterns that correlate with head bending and the activity of RME causally links with head bending amplitude. The undulatory activity of RME is regulated by a pair of cholinergic head motor neurons SMD, which facilitate head bending, and inhibits SMD to limit head bending. The extrasynaptic neurotransmission between SMD and RME provides a gain control system to set head bending amplitude to a value correlated with optimal efficiency of forward movement. DOI: http://dx.doi.org/10.7554/eLife.14197.001 eLife Sciences Publications, Ltd 2016-05-03 /pmc/articles/PMC4854516/ /pubmed/27138642 http://dx.doi.org/10.7554/eLife.14197 Text en © 2016, Shen et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Shen, Yu
Wen, Quan
Liu, He
Zhong, Connie
Qin, Yuqi
Harris, Gareth
Kawano, Taizo
Wu, Min
Xu, Tianqi
Samuel, Aravinthan DT
Zhang, Yun
An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans
title An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans
title_full An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans
title_fullStr An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans
title_full_unstemmed An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans
title_short An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans
title_sort extrasynaptic gabaergic signal modulates a pattern of forward movement in caenorhabditis elegans
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854516/
https://www.ncbi.nlm.nih.gov/pubmed/27138642
http://dx.doi.org/10.7554/eLife.14197
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