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Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure

Sphingomyelin is an essential cellular lipid that traffics between plasma membrane and intracellular organelles until directed to lysosomes for SMPD1 (sphingomyelin phosphodiesterase 1)-mediated degradation. Inactivating mutations in the SMPD1 gene result in Niemann-Pick diseases type A and B charac...

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Detalles Bibliográficos
Autores principales:	Corcelle-Termeau, Elisabeth, Vindeløv, Signe Diness, Hämälistö, Saara, Mograbi, Baharia, Keldsbo, Anne, Bräsen, Jan Hinrich, Favaro, Elena, Adam, Dieter, Szyniarowski, Piotr, Hofman, Paul, Krautwald, Stefan, Farkas, Thomas, Petersen, Nikolaj H.T., Rohde, Mikkel, Linkermann, Andreas, Jäättelä, Marja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2016
Materias:	Basic Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854555/ https://www.ncbi.nlm.nih.gov/pubmed/27070082 http://dx.doi.org/10.1080/15548627.2016.1159378

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