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Development of the Default Mode and Central Executive Networks across early adolescence: A longitudinal study

The mature brain is organized into distinct neural networks defined by regions demonstrating correlated activity during task performance as well as rest. While research has begun to examine differences in these networks between children and adults, little is known about developmental changes during...

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Autores principales: Sherman, Lauren E., Rudie, Jeffrey D., Pfeifer, Jennifer H., Masten, Carrie L., McNealy, Kristin, Dapretto, Mirella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854607/
https://www.ncbi.nlm.nih.gov/pubmed/25282602
http://dx.doi.org/10.1016/j.dcn.2014.08.002
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author Sherman, Lauren E.
Rudie, Jeffrey D.
Pfeifer, Jennifer H.
Masten, Carrie L.
McNealy, Kristin
Dapretto, Mirella
author_facet Sherman, Lauren E.
Rudie, Jeffrey D.
Pfeifer, Jennifer H.
Masten, Carrie L.
McNealy, Kristin
Dapretto, Mirella
author_sort Sherman, Lauren E.
collection PubMed
description The mature brain is organized into distinct neural networks defined by regions demonstrating correlated activity during task performance as well as rest. While research has begun to examine differences in these networks between children and adults, little is known about developmental changes during early adolescence. Using functional magnetic resonance imaging (fMRI), we examined the Default Mode Network (DMN) and the Central Executive Network (CEN) at ages 10 and 13 in a longitudinal sample of 45 participants. In the DMN, participants showed increasing integration (i.e., stronger within-network correlations) between the posterior cingulate cortex (PCC) and the medial prefrontal cortex. During this time frame participants also showed increased segregation (i.e., weaker between-network correlations) between the PCC and the CEN. Similarly, from age 10 to 13, participants showed increased connectivity between the dorsolateral prefrontal cortex and other CEN nodes, as well as increasing DMN segregation. IQ was significantly positively related to CEN integration at age 10, and between-network segregation at both ages. These findings highlight early adolescence as a period of significant maturation for the brain's functional architecture and demonstrate the utility of longitudinal designs to investigate neural network development.
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spelling pubmed-48546072016-05-03 Development of the Default Mode and Central Executive Networks across early adolescence: A longitudinal study Sherman, Lauren E. Rudie, Jeffrey D. Pfeifer, Jennifer H. Masten, Carrie L. McNealy, Kristin Dapretto, Mirella Dev Cogn Neurosci Original Research The mature brain is organized into distinct neural networks defined by regions demonstrating correlated activity during task performance as well as rest. While research has begun to examine differences in these networks between children and adults, little is known about developmental changes during early adolescence. Using functional magnetic resonance imaging (fMRI), we examined the Default Mode Network (DMN) and the Central Executive Network (CEN) at ages 10 and 13 in a longitudinal sample of 45 participants. In the DMN, participants showed increasing integration (i.e., stronger within-network correlations) between the posterior cingulate cortex (PCC) and the medial prefrontal cortex. During this time frame participants also showed increased segregation (i.e., weaker between-network correlations) between the PCC and the CEN. Similarly, from age 10 to 13, participants showed increased connectivity between the dorsolateral prefrontal cortex and other CEN nodes, as well as increasing DMN segregation. IQ was significantly positively related to CEN integration at age 10, and between-network segregation at both ages. These findings highlight early adolescence as a period of significant maturation for the brain's functional architecture and demonstrate the utility of longitudinal designs to investigate neural network development. Elsevier 2014-08-20 /pmc/articles/PMC4854607/ /pubmed/25282602 http://dx.doi.org/10.1016/j.dcn.2014.08.002 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Original Research
Sherman, Lauren E.
Rudie, Jeffrey D.
Pfeifer, Jennifer H.
Masten, Carrie L.
McNealy, Kristin
Dapretto, Mirella
Development of the Default Mode and Central Executive Networks across early adolescence: A longitudinal study
title Development of the Default Mode and Central Executive Networks across early adolescence: A longitudinal study
title_full Development of the Default Mode and Central Executive Networks across early adolescence: A longitudinal study
title_fullStr Development of the Default Mode and Central Executive Networks across early adolescence: A longitudinal study
title_full_unstemmed Development of the Default Mode and Central Executive Networks across early adolescence: A longitudinal study
title_short Development of the Default Mode and Central Executive Networks across early adolescence: A longitudinal study
title_sort development of the default mode and central executive networks across early adolescence: a longitudinal study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854607/
https://www.ncbi.nlm.nih.gov/pubmed/25282602
http://dx.doi.org/10.1016/j.dcn.2014.08.002
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