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The Relevance of Women's Diseases, Jun Activation-domain Binding Protein 1 (JAB1) and p27(kip1)
The Jun activation-domain binding protein 1 (Jab1) recognize a potential coactivator of activator protein 1 (AP-1) such as c-fos, c-jun transcription factor and the fifth subunit of the COP9 signalosome complex. Also, Jab1 activate the c-jun gene resulted cell proliferation. Not only a powerful tumo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Menopause
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854662/ https://www.ncbi.nlm.nih.gov/pubmed/27152307 http://dx.doi.org/10.6118/jmm.2016.22.1.6 |
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author | Kim, Mijin Kim, Tae-Hee Lee, Hae-Hyeog |
author_facet | Kim, Mijin Kim, Tae-Hee Lee, Hae-Hyeog |
author_sort | Kim, Mijin |
collection | PubMed |
description | The Jun activation-domain binding protein 1 (Jab1) recognize a potential coactivator of activator protein 1 (AP-1) such as c-fos, c-jun transcription factor and the fifth subunit of the COP9 signalosome complex. Also, Jab1 activate the c-jun gene resulted cell proliferation. Not only a powerful tumor suppressor but also regulator of apoptosis negative cdk inhibitor p27(kip1) are involved in the cell cycle. This is Jab1 and p27(kip1) interact with each other, Jab1 accelerate p27(kip1) from nuclear to cytoplasm through ubiquitin/proteasome pathway. However, information about the relationship between Jab1 and p27(kip1) is not known much. Taken together, the results of this study identify function and structure of Jab1 and p27(kip1) were described in a recent article on the basis of relevant. Besides Jab1 and p27(kip1) will organize the relationship between the disease and women. |
format | Online Article Text |
id | pubmed-4854662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Society of Menopause |
record_format | MEDLINE/PubMed |
spelling | pubmed-48546622016-05-05 The Relevance of Women's Diseases, Jun Activation-domain Binding Protein 1 (JAB1) and p27(kip1) Kim, Mijin Kim, Tae-Hee Lee, Hae-Hyeog J Menopausal Med Review Article The Jun activation-domain binding protein 1 (Jab1) recognize a potential coactivator of activator protein 1 (AP-1) such as c-fos, c-jun transcription factor and the fifth subunit of the COP9 signalosome complex. Also, Jab1 activate the c-jun gene resulted cell proliferation. Not only a powerful tumor suppressor but also regulator of apoptosis negative cdk inhibitor p27(kip1) are involved in the cell cycle. This is Jab1 and p27(kip1) interact with each other, Jab1 accelerate p27(kip1) from nuclear to cytoplasm through ubiquitin/proteasome pathway. However, information about the relationship between Jab1 and p27(kip1) is not known much. Taken together, the results of this study identify function and structure of Jab1 and p27(kip1) were described in a recent article on the basis of relevant. Besides Jab1 and p27(kip1) will organize the relationship between the disease and women. The Korean Society of Menopause 2016-04 2016-04-26 /pmc/articles/PMC4854662/ /pubmed/27152307 http://dx.doi.org/10.6118/jmm.2016.22.1.6 Text en Copyright © 2016 by The Korean Society of Menopause http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/). |
spellingShingle | Review Article Kim, Mijin Kim, Tae-Hee Lee, Hae-Hyeog The Relevance of Women's Diseases, Jun Activation-domain Binding Protein 1 (JAB1) and p27(kip1) |
title | The Relevance of Women's Diseases, Jun Activation-domain Binding Protein 1 (JAB1) and p27(kip1) |
title_full | The Relevance of Women's Diseases, Jun Activation-domain Binding Protein 1 (JAB1) and p27(kip1) |
title_fullStr | The Relevance of Women's Diseases, Jun Activation-domain Binding Protein 1 (JAB1) and p27(kip1) |
title_full_unstemmed | The Relevance of Women's Diseases, Jun Activation-domain Binding Protein 1 (JAB1) and p27(kip1) |
title_short | The Relevance of Women's Diseases, Jun Activation-domain Binding Protein 1 (JAB1) and p27(kip1) |
title_sort | relevance of women's diseases, jun activation-domain binding protein 1 (jab1) and p27(kip1) |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854662/ https://www.ncbi.nlm.nih.gov/pubmed/27152307 http://dx.doi.org/10.6118/jmm.2016.22.1.6 |
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