Cargando…

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial receptor that recognizes changes in the lipid microenvironment, which may occur during amyloid β (Aβ) accumulation and neuronal degeneration in Alzheimer’s disease (AD). Rare TREM2 variants that affect TREM2 function lead to an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yaming, Ulland, Tyler K., Ulrich, Jason D., Song, Wilbur, Tzaferis, John A., Hole, Justin T., Yuan, Peng, Mahan, Thomas E., Shi, Yang, Gilfillan, Susan, Cella, Marina, Grutzendler, Jaime, DeMattos, Ronald B., Cirrito, John R., Holtzman, David M., Colonna, Marco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854736/ https://www.ncbi.nlm.nih.gov/pubmed/27091843 http://dx.doi.org/10.1084/jem.20151948

Ejemplares similares

ApoE facilitates the microglial response to amyloid plaque pathology
por: Ulrich, Jason D., et al.
Publicado: (2018)

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
por: Ulrich, Jason D, et al.
Publicado: (2014)

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism
por: Song, Wilbur M., et al.
Publicado: (2018)

TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model
por: Wang, Yaming, et al.
Publicado: (2015)

TREM2-Dependent Effects on Microglia in Alzheimer’s Disease
por: Zhou, Yingyue, et al.
Publicado: (2018)

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and - independent cellular responses in Alzheimer’s disease
por: Zhou, Yingyue, et al.
Publicado: (2020)

TREM2 function impedes tau seeding in neuritic plaques
por: Leyns, Cheryl E.G., et al.
Publicado: (2019)

Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
por: Taylor, Xavier, et al.
Publicado: (2023)

IL-15 sustains IL-7R-independent ILC2 and ILC3 development
por: Robinette, Michelle L., et al.
Publicado: (2017)

Loss of TREM2 function increases amyloid seeding but reduces plaque associated ApoE
por: Parhizkar, Samira, et al.
Publicado: (2019)

Microglial Immunometabolism in Alzheimer’s Disease
por: Shippy, Daniel C., et al.
Publicado: (2020)

Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice
por: Delizannis, Argyro Thalia, et al.
Publicado: (2021)

TREM2 triggers microglial density and age‐related neuronal loss
por: Linnartz‐Gerlach, Bettina, et al.
Publicado: (2018)

Fibrillar Amyloid Plaque Formation Precedes Microglial Activation
por: Jung, Christian K. E., et al.
Publicado: (2015)

Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology
por: Sheng, Xuan, et al.
Publicado: (2021)

Impaired Differentiation of Osteoclasts in TREM-2–deficient Individuals
por: Cella, Marina, et al.
Publicado: (2003)

TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities
por: Liu, Zhaoji, et al.
Publicado: (2020)

AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model
por: Hettinger, Jane C., et al.
Publicado: (2018)

TREM2 and APOE do not modulate phagocytic clearance of dying cells in the live mammalian brain
por: Damisah, Eyiyemisi C., et al.
Publicado: (2023)

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)
por: Zhong, Li, et al.
Publicado: (2018)

The biology of TREM receptors
por: Colonna, Marco
Publicado: (2023)

TREM-2 promotes macrophage survival and lung disease after respiratory viral infection
por: Wu, Kangyun, et al.
Publicado: (2015)

Melanoma Differentiation-Associated Gene 5 (MDA5) Is Involved in the Innate Immune Response to Paramyxoviridae Infection In Vivo
por: Gitlin, Leonid, et al.
Publicado: (2010)

Soluble TREM2 induces inflammatory responses and enhances microglial survival
por: Zhong, Li, et al.
Publicado: (2017)

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2
por: Lessard, Christian B, et al.
Publicado: (2018)

Jak3 deficiency blocks innate lymphoid cell development
por: Robinette, Michelle L., et al.
Publicado: (2017)

TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism
por: Zheng, Honghua, et al.
Publicado: (2018)

Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice
por: Zhao, Peng, et al.
Publicado: (2022)

Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition
por: Condello, Carlo, et al.
Publicado: (2011)

Data on TREM-1 activation destabilizing carotid plaques
por: Rao, Velidi H., et al.
Publicado: (2016)

Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
por: Qiao, Wenhui, et al.
Publicado: (2023)

Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal
por: Kang, Silvia S, et al.
Publicado: (2018)

Correction: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
por: Qiao, Wenhui, et al.
Publicado: (2023)

Plasmacytoid Dendritic Cells Contribute to Systemic but Not Local Antiviral Responses to HSV Infections
por: Swiecki, Melissa, et al.
Publicado: (2013)

Divergent Neuroinflammatory Regulation of Microglial TREM Expression and Involvement of NF-κB
por: Owens, Rosie, et al.
Publicado: (2017)

Modulation of microglial phenotypes by dexmedetomidine through TREM2 reduces neuroinflammation in heatstroke
por: Li, Ping, et al.
Publicado: (2021)

Insights from new in vivo models of TREM2 variants
por: Jain, Nimansha, et al.
Publicado: (2023)

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
por: Condello, Carlo, et al.
Publicado: (2015)

Neuronal activity regulates the regional vulnerability to amyloid-β deposition
por: Bero, Adam W., et al.
Publicado: (2011)

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans
por: Xiang, Xianyuan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_h0rbtd4ci1g4kkp3cst2tm5vpq