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Recent Advances in Targetable Therapeutics in Metastatic Non-Squamous NSCLC
Lung adenocarcinoma is the most common subtype of non-small cell lung cancer (NSCLC). With the discovery of epidermal growth factor receptor (EGFR) mutations, anaplastic lymphoma kinase (ALK) rearrangements, and effective targeted therapies, therapeutic options are expanding for patients with lung a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854869/ https://www.ncbi.nlm.nih.gov/pubmed/27200298 http://dx.doi.org/10.3389/fonc.2016.00112 |
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author | Bansal, Pranshu Osman, Diaa Gan, Gregory N. Simon, George R. Boumber, Yanis |
author_facet | Bansal, Pranshu Osman, Diaa Gan, Gregory N. Simon, George R. Boumber, Yanis |
author_sort | Bansal, Pranshu |
collection | PubMed |
description | Lung adenocarcinoma is the most common subtype of non-small cell lung cancer (NSCLC). With the discovery of epidermal growth factor receptor (EGFR) mutations, anaplastic lymphoma kinase (ALK) rearrangements, and effective targeted therapies, therapeutic options are expanding for patients with lung adenocarcinoma. Here, we review novel therapies in non-squamous NSCLC, which are directed against oncogenic targets, including EGFR, ALK, ROS1, BRAF, MET, human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor receptor 2 (VEGFR2), RET, and NTRK. With the rapidly evolving molecular testing and development of new targeted agents, our ability to further personalize therapy in non-squamous NSCLC is rapidly expanding. |
format | Online Article Text |
id | pubmed-4854869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48548692016-05-19 Recent Advances in Targetable Therapeutics in Metastatic Non-Squamous NSCLC Bansal, Pranshu Osman, Diaa Gan, Gregory N. Simon, George R. Boumber, Yanis Front Oncol Oncology Lung adenocarcinoma is the most common subtype of non-small cell lung cancer (NSCLC). With the discovery of epidermal growth factor receptor (EGFR) mutations, anaplastic lymphoma kinase (ALK) rearrangements, and effective targeted therapies, therapeutic options are expanding for patients with lung adenocarcinoma. Here, we review novel therapies in non-squamous NSCLC, which are directed against oncogenic targets, including EGFR, ALK, ROS1, BRAF, MET, human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor receptor 2 (VEGFR2), RET, and NTRK. With the rapidly evolving molecular testing and development of new targeted agents, our ability to further personalize therapy in non-squamous NSCLC is rapidly expanding. Frontiers Media S.A. 2016-05-04 /pmc/articles/PMC4854869/ /pubmed/27200298 http://dx.doi.org/10.3389/fonc.2016.00112 Text en Copyright © 2016 Bansal, Osman, Gan, Simon and Boumber. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Bansal, Pranshu Osman, Diaa Gan, Gregory N. Simon, George R. Boumber, Yanis Recent Advances in Targetable Therapeutics in Metastatic Non-Squamous NSCLC |
title | Recent Advances in Targetable Therapeutics in Metastatic Non-Squamous NSCLC |
title_full | Recent Advances in Targetable Therapeutics in Metastatic Non-Squamous NSCLC |
title_fullStr | Recent Advances in Targetable Therapeutics in Metastatic Non-Squamous NSCLC |
title_full_unstemmed | Recent Advances in Targetable Therapeutics in Metastatic Non-Squamous NSCLC |
title_short | Recent Advances in Targetable Therapeutics in Metastatic Non-Squamous NSCLC |
title_sort | recent advances in targetable therapeutics in metastatic non-squamous nsclc |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854869/ https://www.ncbi.nlm.nih.gov/pubmed/27200298 http://dx.doi.org/10.3389/fonc.2016.00112 |
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