Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice

Loss of strength in human and animal models of aging can be partially attributed to a well‐recognized decrease in muscle mass; however, starting at middle‐age, the normalized force (force/muscle cross‐sectional area) in the knee extensors and single muscle fibers declines in a curvilinear manner. St...

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Detalles Bibliográficos
Autores principales: Zhang, Tan, Pereyra, Andrea S., Wang, Zhong‐Min, Birbrair, Alexander, Reisz, Julie A., Files, Daniel Clark, Purcell, Lina, Feng, Xin, Messi, Maria L., Feng, Hanzhong, Chalovich, Joseph, Jin, Jian‐Ping, Furdui, Cristina, Delbono, Osvaldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854922/
https://www.ncbi.nlm.nih.gov/pubmed/26892246
http://dx.doi.org/10.1111/acel.12453

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