Cargando…

NKX6.1 functions as a metastatic suppressor through epigenetic regulation of the epithelial–mesenchymal transition

The transcription factor NKX6.1 (NK6 homeobox 1) is important in the development of pancreatic β-cells and neurons. Although recent publications show that NKX6.1 is hypermethylated and downregulated during tumorigenesis, the function of NKX6.1 in carcinogenesis remains elusive. Here, we address the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, H-J, Yu, P-N, Huang, K-Y, Su, H-Y, Hsiao, T-H, Chang, C-P, Yu, M-H, Lin, Y-W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855079/ https://www.ncbi.nlm.nih.gov/pubmed/26257059 http://dx.doi.org/10.1038/onc.2015.289

Ejemplares similares

NKX6.1 Represses Tumorigenesis, Metastasis, and Chemoresistance in Colorectal Cancer
por: Chung, Hsin-Hua, et al.
Publicado: (2020)

NKX3.1 Expression Contributes to Epithelial–Mesenchymal Transition of Prostate Cancer Cells
por: Saydullaeva, Iroda, et al.
Publicado: (2023)

Epigenetics, TET proteins, and hypoxia in epithelial-mesenchymal transition and tumorigenesis
por: Chen, Hsiao-Fan, et al.
Publicado: (2016)

Transcriptional Regulation of Notch1 Expression by Nkx6.1 in Neural Stem/Progenitor Cells during Ventral Spinal Cord Development
por: Li, Ying, et al.
Publicado: (2016)

Control of Astrocyte Progenitor Specification, Migration and Maturation by Nkx6.1 Homeodomain Transcription Factor
por: Zhao, Xiaofeng, et al.
Publicado: (2014)

Epigenetic reprogramming in the epithelial-to-mesenchymal transition
por: Hoang, Stephen, et al.
Publicado: (2012)

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity
por: Schaffer, Ashleigh E., et al.
Publicado: (2013)

Progenitor potential of nkx6.1-expressing cells throughout zebrafish life and during beta cell regeneration
por: Ghaye, Aurélie P., et al.
Publicado: (2015)

Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors
por: Aigha, Idil I., et al.
Publicado: (2018)

Epigenetic Regulation of Epithelial to Mesenchymal Transition in the Cancer Metastatic Cascade: Implications for Cancer Therapy
por: Liu, Qiu-Luo, et al.
Publicado: (2021)

LHX6 acts as a novel potential tumour suppressor with epigenetic inactivation in lung cancer
por: Liu, W-b, et al.
Publicado: (2013)

Salinomycin enhances doxorubicin sensitivity through reversing the epithelial-mesenchymal transition of cholangiocarcinoma cells by regulating ARK5
por: Yu, Z., et al.
Publicado: (2017)

Isolation of mineralizing Nestin+ Nkx6.1+ vascular muscular cells from the adult human spinal cord
por: Mamaeva, Daria, et al.
Publicado: (2011)

NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation
por: Aigha, Idil I., et al.
Publicado: (2020)

Deficiency of transcription factor Nkx6.1 does not prevent insulin secretion in INS-1E cells
por: Pavluch, Vojtěch, et al.
Publicado: (2023)

LSD1 mediates MYCN control of epithelial-mesenchymal transition through silencing of metastatic suppressor NDRG1 gene
por: Ambrosio, Susanna, et al.
Publicado: (2016)

Vimentin epigenetic deregulation in Bladder Cancer associates with acquisition of invasive and metastatic phenotype through epithelial-to-mesenchymal transition
por: Monteiro-Reis, Sara, et al.
Publicado: (2023)

Genome-scale epigenetic reprogramming during epithelial to mesenchymal transition
por: McDonald, Oliver G., et al.
Publicado: (2011)

Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1
por: Memon, Bushra, et al.
Publicado: (2018)

Silymarin Induces Expression of Pancreatic Nkx6.1 Transcription Factor and β-Cells Neogenesis in a Pancreatectomy Model
por: Soto, Claudia, et al.
Publicado: (2014)

Micro-RNA-124-5p promotes insulin producing cell differentiation through regulating transcriptional factor NKX6.1
por: Zhang, Xianjun, et al.
Publicado: (2022)

Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications
por: Serrano-Gomez, Silvia Juliana, et al.
Publicado: (2016)

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
por: Sciacovelli, Marco, et al.
Publicado: (2016)

Epigenetic Regulation of the Epithelial to Mesenchymal Transition in Lung Cancer
por: Roche, Joëlle, et al.
Publicado: (2017)

Tackle Epithelial-Mesenchymal Transition With Epigenetic Drugs in Cancer
por: Dong, Bo, et al.
Publicado: (2020)

Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling
por: Yu, Y, et al.
Publicado: (2014)

LincHOTAIR epigenetically silences miR34a by binding to PRC2 to promote the epithelial-to-mesenchymal transition in human gastric cancer
por: Liu, Y-w, et al.
Publicado: (2015)

Prognostic impact of histological categorisation of epithelial–mesenchymal transition in colorectal cancer
por: Ueno, H, et al.
Publicado: (2014)

Correction to: Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1
por: Memon, Bushra, et al.
Publicado: (2018)

The epigenetic modifier trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial–mesenchymal transition of lens epithelial cells
por: Chen, X, et al.
Publicado: (2013)

Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors
por: Walczak, Maciej P., et al.
Publicado: (2016)

Epithelial–mesenchymal transition markers expressed in circulating tumor cells in hepatocellular carcinoma patients with different stages of disease
por: Li, Y-M, et al.
Publicado: (2013)

Epigenetic coordination of signaling pathways during the epithelial-mesenchymal transition
por: Cieślik, Marcin, et al.
Publicado: (2013)

Hypoxia, Epithelial-Mesenchymal Transition, and TET-Mediated Epigenetic Changes
por: Kao, Shih-Han, et al.
Publicado: (2016)

Epigenetic Mechanisms Influencing Epithelial to Mesenchymal Transition in Bladder Cancer
por: Monteiro-Reis, Sara, et al.
Publicado: (2019)

Epigenetic reprogramming of epithelial-mesenchymal transition promotes ferroptosis of head and neck cancer
por: Lee, Jaewang, et al.
Publicado: (2020)

Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis
por: Haque, Inamul, et al.
Publicado: (2011)

SEC61G regulates breast cancer cell proliferation and metastasis by affecting the Epithelial-Mesenchymal Transition
por: Jin, Lingli, et al.
Publicado: (2022)

Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition
por: Malouf, Gabriel G, et al.
Publicado: (2013)

Epithelial-to-mesenchymal transition status of primary breast carcinomas and its correlation with metastatic behavior
por: Savci-Heijink, C. D., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_bg99ons3f7l9v8tg6di29j3kcn