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A prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in Korea

BACKGROUND/AIMS: The objective of this prospective study was to evaluate the diagnosis and treatment of latent tuberculosis infection (LTBI) in adult close contacts of active pulmonary tuberculosis (TB) patients in Korea. METHODS: Adult close contacts of active pulmonary TB patients were recruited a...

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Autores principales: Park, Sun Hyo, Lee, Seung Jun, Cho, Yu Ji, Jeong, Yi Yeong, Kim, Ho Cheol, Lee, Jong Deog, Kim, Hee Jin, Menzies, Dick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855100/
https://www.ncbi.nlm.nih.gov/pubmed/27052266
http://dx.doi.org/10.3904/kjim.2015.095
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author Park, Sun Hyo
Lee, Seung Jun
Cho, Yu Ji
Jeong, Yi Yeong
Kim, Ho Cheol
Lee, Jong Deog
Kim, Hee Jin
Menzies, Dick
author_facet Park, Sun Hyo
Lee, Seung Jun
Cho, Yu Ji
Jeong, Yi Yeong
Kim, Ho Cheol
Lee, Jong Deog
Kim, Hee Jin
Menzies, Dick
author_sort Park, Sun Hyo
collection PubMed
description BACKGROUND/AIMS: The objective of this prospective study was to evaluate the diagnosis and treatment of latent tuberculosis infection (LTBI) in adult close contacts of active pulmonary tuberculosis (TB) patients in Korea. METHODS: Adult close contacts of active pulmonary TB patients were recruited at a regional tertiary hospital in Korea. The participants were tested for LTBI using the tuberculin skin test (TST) and/or QuantiFERON-TB Gold (QFT-G) test. LTBI patients, who consented to treatment, were randomly assigned to receive isoniazid for 9 months (9INH) or rifampin for 4 months (4RIF). RESULTS: We examined 189 adult close contacts (> 18 years) of 107 active pulmonary TB patients. The TST and QFT-G were positive (≥ 10 mm) in 75/183 (39.7%) and 45/118 (38.1%) tested participants, respectively. Among 88 TST or QFT-G positive LTBI participants, 45 participants were randomly assigned to receive 4RIF (n = 21) or 9INH (n = 24), respectively. The average treatment duration for the 4RIF and 9INH groups was 3.3 ± 1.3 and 6.1 ± 2.7 months, respectively. Treatment was completed in 25 participants (4RIF, n = 16; 9INH, n = 9). LTBI participants who accepted treatment were more likely to be women and have more cavitary lesions on the chest radiographs of index cases and positive TST and QFT-G results compared to those who refused treatment. CONCLUSIONS: About 40% of adult close contacts of active pulmonary TB patients had LTBI; about 50% of these LTBI participants agreed to treatment.
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spelling pubmed-48551002016-05-04 A prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in Korea Park, Sun Hyo Lee, Seung Jun Cho, Yu Ji Jeong, Yi Yeong Kim, Ho Cheol Lee, Jong Deog Kim, Hee Jin Menzies, Dick Korean J Intern Med Original Article BACKGROUND/AIMS: The objective of this prospective study was to evaluate the diagnosis and treatment of latent tuberculosis infection (LTBI) in adult close contacts of active pulmonary tuberculosis (TB) patients in Korea. METHODS: Adult close contacts of active pulmonary TB patients were recruited at a regional tertiary hospital in Korea. The participants were tested for LTBI using the tuberculin skin test (TST) and/or QuantiFERON-TB Gold (QFT-G) test. LTBI patients, who consented to treatment, were randomly assigned to receive isoniazid for 9 months (9INH) or rifampin for 4 months (4RIF). RESULTS: We examined 189 adult close contacts (> 18 years) of 107 active pulmonary TB patients. The TST and QFT-G were positive (≥ 10 mm) in 75/183 (39.7%) and 45/118 (38.1%) tested participants, respectively. Among 88 TST or QFT-G positive LTBI participants, 45 participants were randomly assigned to receive 4RIF (n = 21) or 9INH (n = 24), respectively. The average treatment duration for the 4RIF and 9INH groups was 3.3 ± 1.3 and 6.1 ± 2.7 months, respectively. Treatment was completed in 25 participants (4RIF, n = 16; 9INH, n = 9). LTBI participants who accepted treatment were more likely to be women and have more cavitary lesions on the chest radiographs of index cases and positive TST and QFT-G results compared to those who refused treatment. CONCLUSIONS: About 40% of adult close contacts of active pulmonary TB patients had LTBI; about 50% of these LTBI participants agreed to treatment. The Korean Association of Internal Medicine 2016-05 2016-04-07 /pmc/articles/PMC4855100/ /pubmed/27052266 http://dx.doi.org/10.3904/kjim.2015.095 Text en Copyright © 2016 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Sun Hyo
Lee, Seung Jun
Cho, Yu Ji
Jeong, Yi Yeong
Kim, Ho Cheol
Lee, Jong Deog
Kim, Hee Jin
Menzies, Dick
A prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in Korea
title A prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in Korea
title_full A prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in Korea
title_fullStr A prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in Korea
title_full_unstemmed A prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in Korea
title_short A prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in Korea
title_sort prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in korea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855100/
https://www.ncbi.nlm.nih.gov/pubmed/27052266
http://dx.doi.org/10.3904/kjim.2015.095
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