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Heart Rate Variability for Quantification of Autonomic Dysfunction in Fibromyalgia
OBJECTIVE: To quantify autonomic dysfunction in fibromyalgia patients compared to healthy controls using heart rate variability (HRV). METHODS: Sixteen patients with fibromyalgia and 16 healthy controls were recruited in this case control study. HRV was measured using the time-domain method incorpor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Academy of Rehabilitation Medicine
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855125/ https://www.ncbi.nlm.nih.gov/pubmed/27152281 http://dx.doi.org/10.5535/arm.2016.40.2.301 |
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author | Kang, Jin Ho Kim, Jong Kyu Hong, Seok Hyun Lee, Chang Hyun Choi, Byoong Yong |
author_facet | Kang, Jin Ho Kim, Jong Kyu Hong, Seok Hyun Lee, Chang Hyun Choi, Byoong Yong |
author_sort | Kang, Jin Ho |
collection | PubMed |
description | OBJECTIVE: To quantify autonomic dysfunction in fibromyalgia patients compared to healthy controls using heart rate variability (HRV). METHODS: Sixteen patients with fibromyalgia and 16 healthy controls were recruited in this case control study. HRV was measured using the time-domain method incorporating the following parameters: total heartbeats, the mean of intervals between consecutive heartbeats (R-R intervals), the standard deviation of normal to normal R-R intervals (SDNN), the square root of the mean squared differences of successive R-R intervals (RMSSD), ratio of SDNN to RMSSD (SDNN/RMSSD), and difference between the longest and shortest R-R interval under different three conditions including normal quiet breathing, rate controlled breathing, and Valsalva maneuver. The severity of autonomic symptoms in the group of patients with fibromyalgia was measured by Composite Autonomic Symptom Scale 31 (COMPASS 31). Then we analyzed the difference between the fibromyalgia and control groups and the correlation between the COMPASS 31 and aforementioned HRV parameters in the study groups. RESULTS: Patients with fibromyalgia had significantly higher SDNN/RMSSD values under both normal quiet breathing and rate controlled breathing compared to controls. Differences between the longest and shortest R-R interval under Valsalva maneuver were also significantly lower in patients with fibromyalgia than in controls. COMPASS 31 score was negatively correlated with SDNN/RMSSD values under rate controlled breathing. CONCLUSION: SDNN/RMSSD is a valuable parameter for autonomic nervous system function and can be used to quantify subjective autonomic symptoms in patients with fibromyalgia. |
format | Online Article Text |
id | pubmed-4855125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Korean Academy of Rehabilitation Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-48551252016-05-05 Heart Rate Variability for Quantification of Autonomic Dysfunction in Fibromyalgia Kang, Jin Ho Kim, Jong Kyu Hong, Seok Hyun Lee, Chang Hyun Choi, Byoong Yong Ann Rehabil Med Original Article OBJECTIVE: To quantify autonomic dysfunction in fibromyalgia patients compared to healthy controls using heart rate variability (HRV). METHODS: Sixteen patients with fibromyalgia and 16 healthy controls were recruited in this case control study. HRV was measured using the time-domain method incorporating the following parameters: total heartbeats, the mean of intervals between consecutive heartbeats (R-R intervals), the standard deviation of normal to normal R-R intervals (SDNN), the square root of the mean squared differences of successive R-R intervals (RMSSD), ratio of SDNN to RMSSD (SDNN/RMSSD), and difference between the longest and shortest R-R interval under different three conditions including normal quiet breathing, rate controlled breathing, and Valsalva maneuver. The severity of autonomic symptoms in the group of patients with fibromyalgia was measured by Composite Autonomic Symptom Scale 31 (COMPASS 31). Then we analyzed the difference between the fibromyalgia and control groups and the correlation between the COMPASS 31 and aforementioned HRV parameters in the study groups. RESULTS: Patients with fibromyalgia had significantly higher SDNN/RMSSD values under both normal quiet breathing and rate controlled breathing compared to controls. Differences between the longest and shortest R-R interval under Valsalva maneuver were also significantly lower in patients with fibromyalgia than in controls. COMPASS 31 score was negatively correlated with SDNN/RMSSD values under rate controlled breathing. CONCLUSION: SDNN/RMSSD is a valuable parameter for autonomic nervous system function and can be used to quantify subjective autonomic symptoms in patients with fibromyalgia. Korean Academy of Rehabilitation Medicine 2016-04 2016-04-25 /pmc/articles/PMC4855125/ /pubmed/27152281 http://dx.doi.org/10.5535/arm.2016.40.2.301 Text en Copyright © 2016 by Korean Academy of Rehabilitation Medicine http://creativecommons.org/licenses/by-nc/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kang, Jin Ho Kim, Jong Kyu Hong, Seok Hyun Lee, Chang Hyun Choi, Byoong Yong Heart Rate Variability for Quantification of Autonomic Dysfunction in Fibromyalgia |
title | Heart Rate Variability for Quantification of Autonomic Dysfunction in Fibromyalgia |
title_full | Heart Rate Variability for Quantification of Autonomic Dysfunction in Fibromyalgia |
title_fullStr | Heart Rate Variability for Quantification of Autonomic Dysfunction in Fibromyalgia |
title_full_unstemmed | Heart Rate Variability for Quantification of Autonomic Dysfunction in Fibromyalgia |
title_short | Heart Rate Variability for Quantification of Autonomic Dysfunction in Fibromyalgia |
title_sort | heart rate variability for quantification of autonomic dysfunction in fibromyalgia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855125/ https://www.ncbi.nlm.nih.gov/pubmed/27152281 http://dx.doi.org/10.5535/arm.2016.40.2.301 |
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