Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers

Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to prevent CNS diseases. We developed a non-invasive magnetically guided delivery of magneto-electric nanocarriers (MENCs), ~20 nm, 10 mg/kg, ac...

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Detalles Bibliográficos
Autores principales: Kaushik, Ajeet, Jayant, Rahul D., Nikkhah-Moshaie, Roozbeh, Bhardwaj, Vinay, Roy, Upal, Huang, Zaohua, Ruiz, Ariel, Yndart, Adriana, Atluri, Venkata, El-Hage, Nazira, Khalili, Kamel, Nair, Madhavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855156/
https://www.ncbi.nlm.nih.gov/pubmed/27143580
http://dx.doi.org/10.1038/srep25309
Descripción
Sumario:Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to prevent CNS diseases. We developed a non-invasive magnetically guided delivery of magneto-electric nanocarriers (MENCs), ~20 nm, 10 mg/kg, across BBB in C57Bl/J mice. Delivered MENCs were uniformly distributed inside the brain, and were non-toxic to brain and other major organs, such as kidney, lung, liver, and spleen, and did not affect hepatic, kidney and neurobehavioral functioning.

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