Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers

Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to prevent CNS diseases. We developed a non-invasive magnetically guided delivery of magneto-electric nanocarriers (MENCs), ~20 nm, 10 mg/kg, ac...

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Autores principales: Kaushik, Ajeet, Jayant, Rahul D., Nikkhah-Moshaie, Roozbeh, Bhardwaj, Vinay, Roy, Upal, Huang, Zaohua, Ruiz, Ariel, Yndart, Adriana, Atluri, Venkata, El-Hage, Nazira, Khalili, Kamel, Nair, Madhavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855156/
https://www.ncbi.nlm.nih.gov/pubmed/27143580
http://dx.doi.org/10.1038/srep25309
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author Kaushik, Ajeet
Jayant, Rahul D.
Nikkhah-Moshaie, Roozbeh
Bhardwaj, Vinay
Roy, Upal
Huang, Zaohua
Ruiz, Ariel
Yndart, Adriana
Atluri, Venkata
El-Hage, Nazira
Khalili, Kamel
Nair, Madhavan
author_facet Kaushik, Ajeet
Jayant, Rahul D.
Nikkhah-Moshaie, Roozbeh
Bhardwaj, Vinay
Roy, Upal
Huang, Zaohua
Ruiz, Ariel
Yndart, Adriana
Atluri, Venkata
El-Hage, Nazira
Khalili, Kamel
Nair, Madhavan
author_sort Kaushik, Ajeet
collection PubMed
description Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to prevent CNS diseases. We developed a non-invasive magnetically guided delivery of magneto-electric nanocarriers (MENCs), ~20 nm, 10 mg/kg, across BBB in C57Bl/J mice. Delivered MENCs were uniformly distributed inside the brain, and were non-toxic to brain and other major organs, such as kidney, lung, liver, and spleen, and did not affect hepatic, kidney and neurobehavioral functioning.
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spelling pubmed-48551562016-05-16 Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers Kaushik, Ajeet Jayant, Rahul D. Nikkhah-Moshaie, Roozbeh Bhardwaj, Vinay Roy, Upal Huang, Zaohua Ruiz, Ariel Yndart, Adriana Atluri, Venkata El-Hage, Nazira Khalili, Kamel Nair, Madhavan Sci Rep Article Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to prevent CNS diseases. We developed a non-invasive magnetically guided delivery of magneto-electric nanocarriers (MENCs), ~20 nm, 10 mg/kg, across BBB in C57Bl/J mice. Delivered MENCs were uniformly distributed inside the brain, and were non-toxic to brain and other major organs, such as kidney, lung, liver, and spleen, and did not affect hepatic, kidney and neurobehavioral functioning. Nature Publishing Group 2016-05-04 /pmc/articles/PMC4855156/ /pubmed/27143580 http://dx.doi.org/10.1038/srep25309 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Kaushik, Ajeet
Jayant, Rahul D.
Nikkhah-Moshaie, Roozbeh
Bhardwaj, Vinay
Roy, Upal
Huang, Zaohua
Ruiz, Ariel
Yndart, Adriana
Atluri, Venkata
El-Hage, Nazira
Khalili, Kamel
Nair, Madhavan
Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers
title Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers
title_full Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers
title_fullStr Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers
title_full_unstemmed Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers
title_short Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers
title_sort magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855156/
https://www.ncbi.nlm.nih.gov/pubmed/27143580
http://dx.doi.org/10.1038/srep25309
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