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Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain

p21-activated kinases (PAKs) are key regulators of actin dynamics, cell proliferation and cell survival. Deregulation of PAK activity contributes to the pathogenesis of various human diseases, including cancer and neurological disorders. Using an ELISA-based screening protocol, we identified naphtho...

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Detalles Bibliográficos
Autores principales:	Kim, Duk-Joong, Choi, Chang-Ki, Lee, Chan-Soo, Park, Mee-Hee, Tian, Xizhe, Kim, Nam Doo, Lee, Kee-In, Choi, Joong-Kwon, Ahn, Jin Hee, Shin, Eun-Young, Shin, Injae, Kim, Eung-Gook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855275/ https://www.ncbi.nlm.nih.gov/pubmed/27126178 http://dx.doi.org/10.1038/emm.2016.13

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