Nutritional immunology: function of natural killer cells and their modulation by resveratrol for cancer prevention and treatment

Natural killer (NK) cells as part of the innate immune system represent the first line of defence against (virus-) infected and malignantly transformed cells. The emerging field of nutritional immunology focuses on compounds featuring immune-modulating activities in particular on NK cells, which e.g...

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Autores principales: Leischner, Christian, Burkard, Markus, Pfeiffer, Matthias M., Lauer, Ulrich M., Busch, Christian, Venturelli, Sascha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855330/
https://www.ncbi.nlm.nih.gov/pubmed/27142426
http://dx.doi.org/10.1186/s12937-016-0167-8
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author Leischner, Christian
Burkard, Markus
Pfeiffer, Matthias M.
Lauer, Ulrich M.
Busch, Christian
Venturelli, Sascha
author_facet Leischner, Christian
Burkard, Markus
Pfeiffer, Matthias M.
Lauer, Ulrich M.
Busch, Christian
Venturelli, Sascha
author_sort Leischner, Christian
collection PubMed
description Natural killer (NK) cells as part of the innate immune system represent the first line of defence against (virus-) infected and malignantly transformed cells. The emerging field of nutritional immunology focuses on compounds featuring immune-modulating activities in particular on NK cells, which e.g. can be exploited for cancer prevention and treatment. The plant-based nutrition resveratrol is a ternary hydroxylated stilbene, which is present in many foods and beverages, respectively. In humans it comprises a large variety of distinct biological activities. Interestingly, resveratrol strongly modulates the immune response including the activity of NK cells. This review will give an overview on NK cell functions and summarize the resveratrol-mediated modulation thereof.
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spelling pubmed-48553302016-05-05 Nutritional immunology: function of natural killer cells and their modulation by resveratrol for cancer prevention and treatment Leischner, Christian Burkard, Markus Pfeiffer, Matthias M. Lauer, Ulrich M. Busch, Christian Venturelli, Sascha Nutr J Review Natural killer (NK) cells as part of the innate immune system represent the first line of defence against (virus-) infected and malignantly transformed cells. The emerging field of nutritional immunology focuses on compounds featuring immune-modulating activities in particular on NK cells, which e.g. can be exploited for cancer prevention and treatment. The plant-based nutrition resveratrol is a ternary hydroxylated stilbene, which is present in many foods and beverages, respectively. In humans it comprises a large variety of distinct biological activities. Interestingly, resveratrol strongly modulates the immune response including the activity of NK cells. This review will give an overview on NK cell functions and summarize the resveratrol-mediated modulation thereof. BioMed Central 2016-05-04 /pmc/articles/PMC4855330/ /pubmed/27142426 http://dx.doi.org/10.1186/s12937-016-0167-8 Text en © Leischner et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Leischner, Christian
Burkard, Markus
Pfeiffer, Matthias M.
Lauer, Ulrich M.
Busch, Christian
Venturelli, Sascha
Nutritional immunology: function of natural killer cells and their modulation by resveratrol for cancer prevention and treatment
title Nutritional immunology: function of natural killer cells and their modulation by resveratrol for cancer prevention and treatment
title_full Nutritional immunology: function of natural killer cells and their modulation by resveratrol for cancer prevention and treatment
title_fullStr Nutritional immunology: function of natural killer cells and their modulation by resveratrol for cancer prevention and treatment
title_full_unstemmed Nutritional immunology: function of natural killer cells and their modulation by resveratrol for cancer prevention and treatment
title_short Nutritional immunology: function of natural killer cells and their modulation by resveratrol for cancer prevention and treatment
title_sort nutritional immunology: function of natural killer cells and their modulation by resveratrol for cancer prevention and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855330/
https://www.ncbi.nlm.nih.gov/pubmed/27142426
http://dx.doi.org/10.1186/s12937-016-0167-8
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