RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix

Mesenchymal stem cells (MSCs) participate in the repair/remodelling of many tissues, where MSCs commit to different lineages dependent on the cues in the local microenvironment. Here we show that TGFβ-activated RhoA/ROCK signalling functions as a molecular switch regarding the fate of MSCs in arteri...

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Detalles Bibliográficos
Autores principales: Li, Changjun, Zhen, Gehua, Chai, Yu, Xie, Liang, Crane, Janet L., Farber, Emily, Farber, Charles R., Luo, Xianghang, Gao, Peisong, Cao, Xu, Wan, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855537/
https://www.ncbi.nlm.nih.gov/pubmed/27126736
http://dx.doi.org/10.1038/ncomms11455

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