The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing

In this study, we identify signaling network of necrotic cell death induced by transcriptional repression (TRIAD) by α-amanitin (AMA), the selective RNA polymerase II inhibitor, as a model of neurodegenerative cell death. We performed genetic screen of a knockdown (KD) fly library by measuring the r...

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Detalles Bibliográficos
Autores principales: Mao, Y, Tamura, T, Yuki, Y, Abe, D, Tamada, Y, Imoto, S, Tanaka, H, Homma, H, Tagawa, K, Miyano, S, Okazawa, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855646/
https://www.ncbi.nlm.nih.gov/pubmed/27124581
http://dx.doi.org/10.1038/cddis.2016.101

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